C M Swanson1, P J Blatchford2, E S Orwoll3, J A Cauley4, E S LeBlanc5, H A Fink6, K P Wright7,8, M E Wierman7,9, W M Kohrt10, K L Stone11,12. 1. Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Christine.Swanson@UCDenver.edu. 2. Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Aurora, CO, USA. 3. Division of Endocrinology and Bone & Mineral Unit, Oregon Health & Science University, Portland, OR, USA. 4. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. 5. Kaiser Permanente Center for Health Research NW, Portland, OR, USA. 6. Geriatric Research Education and Clinical Center, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA. 7. Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. 8. Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. 9. Research Service, Rocky Mountain Regional Veterans Affairs Medical Center Aurora, Aurora, CO, USA. 10. Division of Geriatric Medicine, and Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 11. Research Institute, California Pacific Medical Center, San Francisco, CA, USA. 12. San Francisco Coordinating Center, University of California San Francisco, San Francisco, CA, USA.
Abstract
Methodological limitations preclude determination of the association between sleep duration and bone mineral density (BMD) from existing literature. This was the first study to use objective sleep duration to determine its association with BMD. Nocturnal sleep duration, assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in postmenopausal women. INTRODUCTION: Both long and short self-reported sleep durations are associated with low bone mineral density (BMD) in men and women. The association between sleep duration measured by actigraphy and BMD in postmenopausal women is unknown. METHODS: The Study of Osteoporotic Fractures (SOF) ancillary sleep study was used to determine the association between sleep duration and BMD at the total hip and femoral neck in postmenopausal women ≥ 75 years old. Sleep duration was assessed by wrist actigraphy (average 4 nights) and questionnaire. BMD was compared between postmenopausal women with short (< 6 h/night) vs. NIH-recommended (7-8 h/night) sleep durations. Data were analyzed using a 2-sample t test (unadjusted) and multivariate regression model (adjusted). Simple linear regression was used to estimate the difference in BMD per additional hour of sleep when sleep duration was considered as a continuous, rather than dichotomized, variable. RESULTS: Total hip BMD was higher in women with actigraphically assessed shorter sleep duration in unadjusted models only. No clinically or statistically significant differences in total hip or femoral neck BMD were observed according to nocturnal sleep duration after adjusting for body mass index (BMI) in dichotomized (N = 874) or continuous (N = 1624) sleep duration models or when subjective sleep duration was used. When sleep duration included daytime naps, longer sleep duration was associated with lower total hip BMD (β = - 0.005, p = 0.04). CONCLUSIONS: Nocturnal sleep duration, whether assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in older postmenopausal women.
Methodological limitations preclude determination of the association between sleep duration and bone mineral density (BMD) from existing literature. This was the first study to use objective sleep duration to determine its association with BMD. Nocturnal sleep duration, assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in postmenopausal women. INTRODUCTION: Both long and short self-reported sleep durations are associated with low bone mineral density (BMD) in men and women. The association between sleep duration measured by actigraphy and BMD in postmenopausal women is unknown. METHODS: The Study of Osteoporotic Fractures (SOF) ancillary sleep study was used to determine the association between sleep duration and BMD at the total hip and femoral neck in postmenopausal women ≥ 75 years old. Sleep duration was assessed by wrist actigraphy (average 4 nights) and questionnaire. BMD was compared between postmenopausal women with short (< 6 h/night) vs. NIH-recommended (7-8 h/night) sleep durations. Data were analyzed using a 2-sample t test (unadjusted) and multivariate regression model (adjusted). Simple linear regression was used to estimate the difference in BMD per additional hour of sleep when sleep duration was considered as a continuous, rather than dichotomized, variable. RESULTS: Total hip BMD was higher in women with actigraphically assessed shorter sleep duration in unadjusted models only. No clinically or statistically significant differences in total hip or femoral neck BMD were observed according to nocturnal sleep duration after adjusting for body mass index (BMI) in dichotomized (N = 874) or continuous (N = 1624) sleep duration models or when subjective sleep duration was used. When sleep duration included daytime naps, longer sleep duration was associated with lower total hip BMD (β = - 0.005, p = 0.04). CONCLUSIONS: Nocturnal sleep duration, whether assessed objectively (actigraphy) or subjectively (questionnaire), was not independently associated with BMD in older postmenopausal women.
Entities:
Keywords:
Actigraphy; Bone mineral density (BMD); Postmenopausal women; Sleep duration
Authors: Christine M Swanson; Prajakta Shanbhag; Emma J Tussey; Corey A Rynders; Kenneth P Wright; Wendy M Kohrt Journal: Calcif Tissue Int Date: 2022-02-08 Impact factor: 4.000
Authors: W M Kohrt; E S Orwoll; C M Swanson; P J Blatchford; K L Stone; J A Cauley; N E Lane; T S Rogers-Soeder; S Redline; D C Bauer; K P Wright; M E Wierman Journal: Osteoporos Int Date: 2020-09-15 Impact factor: 4.507
Authors: Christopher M Depner; John D Rice; Emma J Tussey; Robert H Eckel; Bryan C Bergman; Janine A Higgins; Edward L Melanson; Wendy M Kohrt; Kenneth P Wright; Christine M Swanson Journal: Bone Date: 2021-06-30 Impact factor: 4.398