Literature DB >> 3113670

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease.

J H Morrison, D A Lewis, M J Campbell, G W Huntley, D L Benson, C Bouras.   

Abstract

Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.

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Year:  1987        PMID： 3113670     DOI： 10.1016/0006-8993(87)90914-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  29 in total

1.  Sensory evoked and event related oscillations in Alzheimer's disease: a short review.

Authors:  Görsev G Yener; Erol Başar
Journal:  Cogn Neurodyn       Date:  2010-10-21       Impact factor: 5.082

2.  Neurofilament protein triplet immunoreactivity in the dorsal root ganglia of the guinea-pig.

Authors:  J C Vickers; M Costa
Journal:  Cell Tissue Res       Date:  1991-07       Impact factor: 5.249

3.  Differential expression of cytoskeletal genes in the cochlear nucleus.

Authors:  David R Friedland; Paul Popper; Rebecca Eernisse; Benjamin Ringger; Joseph A Cioffi
Journal:  Anat Rec A Discov Mol Cell Evol Biol       Date:  2006-04

4.  Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs.

Authors:  Parvathi Rudrabhatla; Howard Jaffe; Harish C Pant
Journal:  FASEB J       Date:  2011-08-09       Impact factor: 5.191

5.  Distinctive morphological features of a subset of cortical neurons grown in the presence of basal forebrain neurons in vitro.

Authors:  D H Ha; R T Robertson; J H Weiss
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

6.  Geometric Navigation of Axons in a Cerebral Pathway: Comparing dMRI with Tract Tracing and Immunohistochemistry.

Authors:  Farzad Mortazavi; Adrian L Oblak; Will Z Morrison; Jeremy D Schmahmann; H Eugene Stanley; Van J Wedeen; Douglas L Rosene
Journal:  Cereb Cortex       Date:  2018-04-01       Impact factor: 5.357

7.  Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ.

Authors:  Parvathi Rudrabhatla; Philip Grant; Howard Jaffe; Michael J Strong; Harish C Pant
Journal:  FASEB J       Date:  2010-07-12       Impact factor: 5.191

8.  Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.

Authors:  Takahide Kaji; Barry Boland; Tatjana Odrljin; Panaiyur Mohan; Balapal S Basavarajappa; Corrinne Peterhoff; Anne Cataldo; Anna Rudnicki; Niranjana Amin; Bing Sheng Li; Harish C Pant; Basalingappa L Hungund; Ottavio Arancio; Ralph A Nixon
Journal:  Am J Pathol       Date:  2004-09       Impact factor: 4.307

9.  Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.

Authors:  Alexander Schulz; Stephan L Baader; Michiko Niwa-Kawakita; Marie Juliane Jung; Reinhard Bauer; Cynthia Garcia; Ansgar Zoch; Stephan Schacke; Christian Hagel; Victor-Felix Mautner; C Oliver Hanemann; Xin-Peng Dun; David B Parkinson; Joachim Weis; J Michael Schröder; David H Gutmann; Marco Giovannini; Helen Morrison
Journal:  Nat Neurosci       Date:  2013-03-03       Impact factor: 24.884

10.  Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus.

Authors:  Afia Akram; James Schmeidler; Pavel Katsel; Patrick R Hof; Vahram Haroutunian
Journal:  Brain Res       Date:  2010-01-14       Impact factor: 3.252
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