| Literature DB >> 3113490 |
E Diez, J Balsinde, M Aracil, A Schüller.
Abstract
Exposure of mouse peritoneal macrophages to ethanol induces a rapid release of arachidonic acid to the extracellular medium. All major classes of phospholipids, phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol contribute to this release. Ethanol-induced mobilization of arachidonic acid occurs by deacylation, but it is not accompanied by eicosanoid synthesis. These data suggest that at least two signals are necessary for the release and metabolism of arachidonic acid. Ethanol also activates a phospholipase C which hydrolyzes only phosphatidylinositol, and not its phosphorylated derivatives.Entities:
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Year: 1987 PMID： 3113490 DOI： 10.1016/0005-2760(87)90173-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002