| Literature DB >> 31134502 |
Kristina Schiavone1, Delphine Garnier2, Marie-Francoise Heymann2, Dominique Heymann3,4.
Abstract
Osteosarcoma is the most common bone sarcoma and is one of the cancer entities characterized by the highest level of heterogeneity in humans. This heterogeneity takes place not only at the macroscopic and microscopic levels, with heterogeneous micro-environmental components, but also at the genomic, transcriptomic and epigenetic levels. Recent investigations have revealed the existence in osteosarcoma of cancer cells with stemness properties. Cancer stem cells are characterized by their specific phenotype and low cycling capacity, and are linked to drug resistance, tumour growth and the metastatic process. In addition, cancer stem cells contribute to the enrichment of tumour heterogeneity. The present manuscript will describe the main characteristic features of cancer stem cells in osteosarcoma and will discuss their impact on maintaining tumour heterogeneity. Their clinical implications will also be briefly addressed.Entities:
Keywords: Cancer stem cell; Cancer stem-like cells; Cell dormancy; Circulating tumour cells; Clinical trials; Drug resistance; Gene mutation drivers; Monitoring; Osteosarcoma; Tumour heterogeneity
Mesh：
Year: 2019 PMID： 31134502 DOI： 10.1007/978-3-030-14366-4_11
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622