Literature DB >> 3113422

13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells.

B N Setty, M Berger, M J Stuart.   

Abstract

The effect of 13-hydroxyoctadecadienoic acid (13-HODE), an endogenous lipoxygenase metabolite of linoleic acid, on prostacyclin production by fetal bovine aortic endothelial cells was evaluated. Time-dependent release of radioimmunoassayable 6KPGF1 alpha in the presence of 13-HODE (10 uM) was stimulated by 39%, 27%, and 34% at 10, 30 and 120 min respectively. 13-HODE (10 uM) had no effect on the conversion of exogenous [14C] arachidonic acid (AA) to prostacyclin. When the effect on AA release was evaluated in [14C] AA prelabeled cells, 13-HODE (10nM) stimulated the release of AA from membrane phospholipids. Analysis of cellular phospholipids revealed a significant decrease in phosphatidylethanolamine. Our results demonstrate that 13-HODE stimulates prostacyclin production by enhancing AA release from phospholipids.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 3113422     DOI： 10.1016/0006-291x(87)90557-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Analysis by fast-atom bombardment tandem mass spectrometry of phosphatidylcholine isolated from heart mitochondrial fractions: Evidence of incorporation of monohydroxylated fatty acyl moieties.

Authors:  S Ponchautcor; K Veitchaff; R Libertaff; F Van Hoofaff; L Hueaff; E de Hoffmann
Journal:  J Am Soc Mass Spectrom       Date:  1996-01       Impact factor: 3.109

Review 2.  Metabolic interactions between eicosanoids in blood and vascular cells.

Authors:  M Lagarde; N Gualde; M Rigaud
Journal:  Biochem J       Date:  1989-01-15       Impact factor: 3.857

3.  Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells.

Authors:  M J Oosthuizen; F Engels; B Van Esch; P A Henricks; F P Nijkamp
Journal:  Inflammation       Date:  1990-08       Impact factor: 4.092

4.  Hydroxyoctadecadienoic acids: novel regulators of macrophage differentiation and atherogenesis.

Authors:  Venkat Vangaveti; Bernhard T Baune; R Lee Kennedy
Journal:  Ther Adv Endocrinol Metab       Date:  2010-04       Impact factor: 3.565

5.  Bioactive Oxylipins in Infants and Children With Congenital Heart Disease Undergoing Pediatric Cardiopulmonary Bypass.

Authors:  Nahmah Kim-Campbell; Catherine Gretchen; Vladimir B Ritov; Patrick M Kochanek; Goundappa K Balasubramani; Elizabeth Kenny; Mahesh Sharma; Melita Viegas; Clifton Callaway; Valerian E Kagan; Hülya Bayír
Journal:  Pediatr Crit Care Med       Date:  2020-01       Impact factor: 3.624

6.  Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

Authors:  J Shen; E Herderick; J F Cornhill; E Zsigmond; H S Kim; H Kühn; N V Guevara; L Chan
Journal:  J Clin Invest       Date:  1996-11-15       Impact factor: 14.808

7.  The role of endothelial cells in the relaxations induced by 13-hydroxy- and 13-hydroperoxylinoleic acid in canine arteries.

Authors:  G R De Meyer; H Bult; T J Verbeuren; A G Herman
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

8.  The Plasma Oxylipin Signature Provides a Deep Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria.

Authors:  Céline Dalle; Jérémy Tournayre; Malwina Mainka; Alicja Basiak-Rasała; Mélanie Pétéra; Sophie Lefèvre-Arbogast; Jessica Dalloux-Chioccioli; Mélanie Deschasaux-Tanguy; Lucie Lécuyer; Emmanuelle Kesse-Guyot; Léopold K Fezeu; Serge Hercberg; Pilar Galan; Cécilia Samieri; Katarzyna Zatońska; Philip C Calder; Mads Fiil Hjorth; Arne Astrup; André Mazur; Justine Bertrand-Michel; Nils Helge Schebb; Andrzej Szuba; Mathilde Touvier; John W Newman; Cécile Gladine
Journal:  Int J Mol Sci       Date:  2022-10-02       Impact factor: 6.208
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.