Jae-Woo Lee1, Na-Young You2, Yeseul Kim1, Yonghwan Kim3, Joungyoun Kim4, Hee-Taik Kang5. 1. Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea. 2. Department of Information & Statistics, Chungbuk National University, Cheongju, Republic of Korea. 3. Department of Family Medicine, Yonsei University College of medicine, Seoul, Republic of Korea. 4. Department of Information & Statistics, Chungbuk National University, Cheongju, Republic of Korea. Electronic address: joungyoun@chungbuk.ac.kr. 5. Department of Family Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea; Department of Family Medicine, Chungbuk National University College of Medicine, Cheongju, Chungbuk, Republic of Korea. Electronic address: kanght0818@gmail.com.
Abstract
BACKGROUND AND AIMS: We investigated the association between statin use and site-specific risk of colorectal cancer in individuals with hypercholesterolemia. METHODS AND RESULTS: This study is based on the National Health Insurance Service-National Health Screening Cohort, conducted during 2002-2015. Statin users were classified as high and low users according to medication possession ratio (MPR). Statin nonusers comprised participants who did not use statins during the entire follow-up period. In total, 17,737 statin users and 13,412 statin nonusers were included in the analysis, with a median follow-up period of 12.7 years. Cox proportional hazards regression models were adopted after stepwise adjustment for confounders to investigate prospective association between statin usage and colorectal cancer risk. In total, 378 (2.3%) of 16,588 male participants and 239 (1.6%) of 14,561 female participants had colorectal cancer during the follow-up period. Compared to nonusers, fully adjusted hazard ratios (HRs) (95% confidence intervals [95% CIs]) for colorectal cancer risk in high statin users were 0.56 (0.42-0.75) in men and 0.64 (0.46-0.90) in women. In men, the fully adjusted HRs for proximal and rectal cancer for high users were 0.29 (0.15-0.56) and 0.52 (0.35-0.78), respectively, compared to those for nonusers. In women, statistical significance was seen only in rectal cancer (HR 0.43 [0.25-0.72]) but not in proximal or distal colon cancer. CONCLUSIONS: High statin users with hypercholesterolemia were associated with lower risk of overall colorectal cancer, especially proximal colon cancer in men and rectal cancer in both sexes.
BACKGROUND AND AIMS: We investigated the association between statin use and site-specific risk of colorectal cancer in individuals with hypercholesterolemia. METHODS AND RESULTS: This study is based on the National Health Insurance Service-National Health Screening Cohort, conducted during 2002-2015. Statin users were classified as high and low users according to medication possession ratio (MPR). Statin nonusers comprised participants who did not use statins during the entire follow-up period. In total, 17,737 statin users and 13,412 statin nonusers were included in the analysis, with a median follow-up period of 12.7 years. Cox proportional hazards regression models were adopted after stepwise adjustment for confounders to investigate prospective association between statin usage and colorectal cancer risk. In total, 378 (2.3%) of 16,588 male participants and 239 (1.6%) of 14,561 female participants had colorectal cancer during the follow-up period. Compared to nonusers, fully adjusted hazard ratios (HRs) (95% confidence intervals [95% CIs]) for colorectal cancer risk in high statin users were 0.56 (0.42-0.75) in men and 0.64 (0.46-0.90) in women. In men, the fully adjusted HRs for proximal and rectal cancer for high users were 0.29 (0.15-0.56) and 0.52 (0.35-0.78), respectively, compared to those for nonusers. In women, statistical significance was seen only in rectal cancer (HR 0.43 [0.25-0.72]) but not in proximal or distal colon cancer. CONCLUSIONS: High statin users with hypercholesterolemia were associated with lower risk of overall colorectal cancer, especially proximal colon cancer in men and rectal cancer in both sexes.
Authors: Yin Zhang; Kana Wu; Andrew T Chan; Jeffrey A Meyerhardt; Edward L Giovannucci Journal: Am J Gastroenterol Date: 2022-01-01 Impact factor: 12.045
Authors: Shu-Hua Hsu; De-Kai Syu; Yong-Chen Chen; Chih-Kuang Liu; Chien-An Sun; Mingchih Chen Journal: Int J Environ Res Public Health Date: 2022-06-25 Impact factor: 4.614
Authors: Rhea Harewood; Ruth Disney; James Kinross; Christian von Wagner; Amanda J Cross Journal: Cancer Causes Control Date: 2021-07-05 Impact factor: 2.506