Junjia Lu1, Dechang Mao2, Xiang Li3, Yunqiang Ma4, Yunqi Luan5, Yong Cao6, Yunpeng Luan7. 1. College of Biodiversity Conservation and Utilisation, Southwest University, United States. 2. Department of Life Technology Teaching and Research, School of Life Science, Southwest Forestry University, PR China. 3. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China. 4. Rearch Institute of Resources and Insects, Chinese Academy of Forestry Chinese Academy of Forest, Kunming, 650224, PR China. 5. Lomonosov Moscow State University, Russia. 6. Department of Life Technology Teaching and Research, College of Life Sciences, Southwest Forestry University, PR China. 7. Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, PR China; Department of Life Technology Teaching and Research, School of Life Science, Southwest Forestry University, PR China. Electronic address: 1820059756@qq.com.
Abstract
OBJECTIVES: This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. METHODS: Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose stools rates, diarrhea rates, diarrhea index and motor functions of intestine. RESULTS: Our results showed that all three kinds of extracts from Psidium guajava L. had inhibitory effects on Folium Sennae -induced diarrhea model. The proportion of Bacteroidetes is lower in Group DF (diarrhea model group) compared with Group B (blank group), while abundance of Deferribacteraceae was found in Group DF. The proportion of Deferribacteraceae lowered in Group DTF (diarrhea treatment group) treated with extracts from Psidium guajava L. CONCLUSIONS: However, mechanisms underlying the therapeutic effect of Psidium guajava L. and the changes in intestinal microflora still await further exploration.
OBJECTIVES: This study aimed to explore the effects of Psidium guajava L. extracts on micediarrhea model and changes in their intestinal microflora diversity. METHODS:Micediarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose stools rates, diarrhea rates, diarrhea index and motor functions of intestine. RESULTS: Our results showed that all three kinds of extracts from Psidium guajava L. had inhibitory effects on Folium Sennae -induced diarrhea model. The proportion of Bacteroidetes is lower in Group DF (diarrhea model group) compared with Group B (blank group), while abundance of Deferribacteraceae was found in Group DF. The proportion of Deferribacteraceae lowered in Group DTF (diarrhea treatment group) treated with extracts from Psidium guajava L. CONCLUSIONS: However, mechanisms underlying the therapeutic effect of Psidium guajava L. and the changes in intestinal microflora still await further exploration.