Ocular coloboma associated with a solitary maxillary central incisor and growth failure: manifestations of holoprosencephaly.

A one-year-old boy presented with findings of ocular colobomas and staphylomas in both eyes. He also had a single central incisor and growth failure. His mother had hyposmia. We think that the patient and his mother represent the mild end of the spectrum of autosomal dominant holoprosencephaly.