| Literature DB >> 31132513 |
Yingying Zhao1, Yanjun Chu1, Jing Sun1, Ruifeng Song1, Ya Li1, Feng Xu2.
Abstract
LncRNA GAS8-AS1 inhibits thyroid carcinoma, while its role in colorectal cancer (CRC) is unknown. In the present study we found that plasma GAS8-AS1 was upregulated in early stage CRC patients, and downregulation of GAS8-AS1 effectively distinguished CRC patients from healthy controls. LncRNA AFAP1-AS1 was upregulated in CRC patients and was inversely correlated with GAS8-AS1 only in CRC patients but not in healthy controls. GAS8-AS1 overexpression mediated the downregulation of AFAP1-AS1 in colon cancer cells, while AFAP1-AS1 overexpression did not significantly affect GAS8-AS1 expression. Expression level of GAS8-AS1 decreased, while expression level of AFAP1-AS1 increased with the increase of primary tumor diameters. GAS8-AS1 overexpression led to inhibited, while AFAP1-AS1 overexpression led to promoted proliferation of CRC cells, and AFAP1-AS1 overexpression reduced the inhibitory effects of GAS8-AS1 overexpression on cancer cell proliferation. Therefore, GAS8-AS may inhibit CRC cell proliferation by downregulating AFAP1-AS1.Entities:
Keywords: Colorectal cancer; Proliferation; lncRNA AFAP1-AS1; lncRNA GAS8-AS1
Mesh：
Substances：
Year: 2019 PMID： 31132513 DOI： 10.1016/j.gene.2019.05.040
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688