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Literature DB >> 31131941

Microglia: Lifelong modulator of neural circuits.

Ako Ikegami¹, Koichiro Haruwaka¹, Hiroaki Wake^1,2.

Abstract

Microglia, the sole immune cells in the brain, are the key player for synaptic regulation required for our brain function in both developing and adult brain. They have highly motile processes to detect synaptic functions. Recent accumulated studies have unveiled the mechanism underlying synapse detection and pruning / formation by microglia. In this review, we summarize the current knowledge of various microglial machinery recruited in synaptic modulation in the different life stages and contexts.

Keywords: glia; in vivo imaging; microglia; neural circuits; synapses

Mesh：

Year: 2019 PMID： 31131941 DOI： 10.1111/neup.12560

Source DB: PubMed Journal: Neuropathology ISSN： 0919-6544 Impact factor: 1.906

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Cited

11 in total

1. Characterization of proinflammatory markers in the ventral tegmental area across mouse models of chronic stress.

Authors: Vedrana Bali; Sarah C Simmons; Claire E Manning; Marie A Doyle; Minerva Rodriguez; Ali R Stark; Shantée N Ayala Rosario; A J Robison; Michelle S Mazei-Robison
Journal: Neuroscience Date: 2021-03-06 Impact factor: 3.590

2. Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure.

Authors: Rebecca L Lowery; MaKenna Y Cealie; Cassandra E Lamantia; Monique S Mendes; Paul D Drew; Ania K Majewska
Journal: J Neurosci Res Date: 2021-02-19 Impact factor: 4.433

Review 3. Reactive Glia Inflammatory Signaling Pathways and Epilepsy.

Authors: Pascual Sanz; Maria Adelaida Garcia-Gimeno
Journal: Int J Mol Sci Date: 2020-06-08 Impact factor: 5.923

4. Necroptosis and Caspase-2-Mediated Apoptosis of Astrocytes and Neurons, but Not Microglia, of Rat Hippocampus and Parenchyma Caused by Angiostrongylus cantonensis Infection.

Authors: Hongli Zhou; Zhe Chen; Yanin Limpanont; Yue Hu; Yubin Ma; Ping Huang; Paron Dekumyoy; Minyu Zhou; Yixin Cheng; Zhiyue Lv
Journal: Front Microbiol Date: 2020-01-23 Impact factor: 5.640

Review 5. Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation.

Authors: Carolina Araújo Moraes; Camila Zaverucha-do-Valle; Renaud Fleurance; Tarek Sharshar; Fernando Augusto Bozza; Joana d'Avila
Journal: Pharmaceuticals (Basel) Date: 2021-05-01

Review 6. Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States.

Authors: Dario Carvalho-Paulo; João Bento Torres Neto; Carlos Santos Filho; Thais Cristina Galdino de Oliveira; Aline Andrade de Sousa; Renata Rodrigues Dos Reis; Zaire Alves Dos Santos; Camila Mendes de Lima; Marcus Augusto de Oliveira; Nivin Mazen Said; Sinara Franco Freitas; Marcia Consentino Kronka Sosthenes; Giovanni Freitas Gomes; Ediely Pereira Henrique; Patrick Douglas Côrrea Pereira; Lucas Silva de Siqueira; Mauro André Damasceno de Melo; Cristovam Guerreiro Diniz; Nara Gyzely de Morais Magalhães; José Antonio Picanço Diniz; Pedro Fernando da Costa Vasconcelos; Daniel Guerreiro Diniz; Daniel Clive Anthony; David Francis Sherry; Dora Brites; Cristovam Wanderley Picanço Diniz
Journal: Front Immunol Date: 2021-06-18 Impact factor: 7.561

Microglia: Lifelong modulator of neural circuits.

1. Characterization of proinflammatory markers in the ventral tegmental area across mouse models of chronic stress.

2. Microglia and astrocytes show limited, acute alterations in morphology and protein expression following a single developmental alcohol exposure.

Review 3. Reactive Glia Inflammatory Signaling Pathways and Epilepsy.

4. Necroptosis and Caspase-2-Mediated Apoptosis of Astrocytes and Neurons, but Not Microglia, of Rat Hippocampus and Parenchyma Caused by Angiostrongylus cantonensis Infection.

Review 5. Neuroinflammation in Sepsis: Molecular Pathways of Microglia Activation.

Review 6. Microglial Morphology Across Distantly Related Species: Phylogenetic, Environmental and Age Influences on Microglia Reactivity and Surveillance States.

Review 7. Connexins-Based Hemichannels/Channels and Their Relationship with Inflammation, Seizures and Epilepsy.

Review 8. Neurocognitive impacts of arbovirus infections.

Review 9. Microglia in Prion Diseases: Angels or Demons?

Review 10. An emerging role for microglia in stress-effects on memory.