| Literature DB >> 31131462 |
Dominic Magirr1, Carl-Fredrik Burman1.
Abstract
We propose a new class of weighted logrank tests (WLRTs) that control the risk of concluding that a new drug is more efficacious than standard of care, when, in fact, it is uniformly inferior. Perhaps surprisingly, this risk is not controlled for WLRT in general. Tests from this new class can be constructed to have high power under a delayed-onset treatment effect scenario, as well as being almost as efficient as the standard logrank test under proportional hazards.Keywords: drug regulation; immuno-oncology; nonproportional hazards; weighted logrank test
Mesh:
Year: 2019 PMID: 31131462 DOI: 10.1002/sim.8186
Source DB: PubMed Journal: Stat Med ISSN: 0277-6715 Impact factor: 2.373