Literature DB >> 31131310

Mechanical forces rewire metabolism in the tumor niche.

Thomas Bertero1, Cedric Gaggioli2.   

Abstract

Tumor niche extracellular matrix stiffening and tumor cell metabolic reprogramming are two fundamental mediators of tumor progression. We recently elucidated a mechanistic interconnection between mechanotransduction and tumor metabolic rewiring in cancer. We demonstrated a stiffness-dependent amino acid crosstalk between stromal and cancer cells that fuels tumor progression and metastatic spreading.

Entities:  

Keywords:  Cancer progression; YAP/TAZ; cancer-associated fibroblast; mechanotransduction; tumor cell metabolism

Year:  2019        PMID： 31131310      PMCID： PMC6512933          DOI： 10.1080/23723556.2019.1592945

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Authors:  Thomas Bertero; Katherine A Cottrill; Yu Lu; Christina M Haeger; Paul Dieffenbach; Sofia Annis; Andrew Hale; Balkrishen Bhat; Vivek Kaimal; Ying-Yi Zhang; Brian B Graham; Rahul Kumar; Rajan Saggar; Rajeev Saggar; W Dean Wallace; David J Ross; Stephen M Black; Sohrab Fratz; Jeffrey R Fineman; Sara O Vargas; Kathleen J Haley; Aaron B Waxman; B Nelson Chau; Laura E Fredenburgh; Stephen Y Chan
Journal:  Cell Rep       Date:  2015-10-22       Impact factor: 9.423

2.  Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

Authors:  Lifeng Yang; Abhinav Achreja; Tsz-Lun Yeung; Lingegowda S Mangala; Dahai Jiang; Cecil Han; Joelle Baddour; Juan C Marini; Joseph Ni; Ryuichi Nakahara; Stephen Wahlig; Lisa Chiba; Sun Hye Kim; Joshua Morse; Sunila Pradeep; Archana Sidalaghatta Nagaraja; Monika Haemmerle; Noh Kyunghee; Mathew Derichsweiler; Thomas Plackemeier; Imelda Mercado-Uribe; Gabriel Lopez-Berestein; Tyler Moss; Prahlad T Ram; Jinsong Liu; Xiongbin Lu; Samuel C Mok; Anil K Sood; Deepak Nagrath
Journal:  Cell Metab       Date:  2016-11-08       Impact factor: 27.287

Review 3.  The extracellular matrix modulates the hallmarks of cancer.

Authors:  Michael W Pickup; Janna K Mouw; Valerie M Weaver
Journal:  EMBO Rep       Date:  2014-11-08       Impact factor: 8.807

4.  Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

Authors:  Elena Enzo; Giulia Santinon; Arianna Pocaterra; Mariaceleste Aragona; Silvia Bresolin; Mattia Forcato; Daniela Grifoni; Annalisa Pession; Francesca Zanconato; Giulia Guzzo; Silvio Bicciato; Sirio Dupont
Journal:  EMBO J       Date:  2015-03-21       Impact factor: 11.598

Review 5.  Mechanobiology of YAP and TAZ in physiology and disease.

Authors:  Tito Panciera; Luca Azzolin; Michelangelo Cordenonsi; Stefano Piccolo
Journal:  Nat Rev Mol Cell Biol       Date:  2017-09-27       Impact factor: 94.444

6.  Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.

Authors:  Thomas Bertero; William M Oldham; Katherine A Cottrill; Sabrina Pisano; Rebecca R Vanderpool; Qiujun Yu; Jingsi Zhao; Yiyin Tai; Ying Tang; Ying-Yi Zhang; Sofiya Rehman; Masataka Sugahara; Zhi Qi; John Gorcsan; Sara O Vargas; Rajan Saggar; Rajeev Saggar; W Dean Wallace; David J Ross; Kathleen J Haley; Aaron B Waxman; Victoria N Parikh; Teresa De Marco; Priscilla Y Hsue; Alison Morris; Marc A Simon; Karen A Norris; Cedric Gaggioli; Joseph Loscalzo; Joshua Fessel; Stephen Y Chan
Journal:  J Clin Invest       Date:  2016-08-22       Impact factor: 14.808

7.  Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

Authors:  Thomas Bertero; William M Oldham; Eloise M Grasset; Isabelle Bourget; Etienne Boulter; Sabrina Pisano; Paul Hofman; Floriant Bellvert; Guerrino Meneguzzi; Dmitry V Bulavin; Soline Estrach; Chloe C Feral; Stephen Y Chan; Alexandre Bozec; Cedric Gaggioli
Journal:  Cell Metab       Date:  2018-10-04       Impact factor: 27.287

8.  AMPK modulates Hippo pathway activity to regulate energy homeostasis.

Authors:  Wenqi Wang; Zhen-Dong Xiao; Xu Li; Kathryn E Aziz; Boyi Gan; Randy L Johnson; Junjie Chen
Journal:  Nat Cell Biol       Date:  2015-03-09       Impact factor: 28.824

9.  Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK.

Authors:  Jennifer L Bays; Hannah K Campbell; Christy Heidema; Michael Sebbagh; Kris A DeMali
Journal:  Nat Cell Biol       Date:  2017-05-29       Impact factor: 28.824

10.  Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Authors:  Cristovão M Sousa; Douglas E Biancur; Xiaoxu Wang; Christopher J Halbrook; Mara H Sherman; Li Zhang; Daniel Kremer; Rosa F Hwang; Agnes K Witkiewicz; Haoqiang Ying; John M Asara; Ronald M Evans; Lewis C Cantley; Costas A Lyssiotis; Alec C Kimmelman
Journal:  Nature       Date:  2016-08-10       Impact factor: 49.962
  10 in total
  5 in total

Review 1.  Integrating Biophysics in Toxicology.

Authors:  Giorgia Del Favero; Annette Kraegeloh
Journal:  Cells       Date:  2020-05-21       Impact factor: 6.600

Review 2.  Role of the mechanical microenvironment in cancer development and progression.

Authors:  Qiuping Liu; Qing Luo; Yang Ju; Guanbin Song
Journal:  Cancer Biol Med       Date:  2020-05-15       Impact factor: 4.248

3.  Inward Outward Signaling in Ovarian Cancer: Morpho-Phospho-Proteomic Profiling Upon Application of Hypoxia and Shear Stress Characterizes the Adaptive Plasticity of OVCAR-3 and SKOV-3 Cells.

Authors:  Andrea Bileck; Patricia Bortel; Michelle Kriz; Lukas Janker; Endre Kiss; Christopher Gerner; Giorgia Del Favero
Journal:  Front Oncol       Date:  2022-02-14       Impact factor: 6.244

Review 4.  Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology.

Authors:  Simon Lecoutre; Mélanie Lambert; Krzysztof Drygalski; Isabelle Dugail; Salwan Maqdasy; Mathieu Hautefeuille; Karine Clément
Journal:  Cells       Date:  2022-07-27       Impact factor: 7.666

Review 5.  Role of extracellular matrix architecture and signaling in melanoma therapeutic resistance.

Authors:  Ana Popovic; Sophie Tartare-Deckert
Journal:  Front Oncol       Date:  2022-09-02       Impact factor: 5.738
  5 in total

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