Hülya Olgun Yazar1, Tamer Yazar2, Sonay Özdemir3, Yeliz Kasko Arici4. 1. Ordu University Training and Research Hospital, Neurology, Ordu, Turkey. Electronic address: hulyazar@yahoo.com. 2. Ordu State Hospital, Neurology, Ordu, Turkey. 3. İstanbul Gaziosmanpaşa Taksim Training and Research Hospital, Family Medicine, İstanbul, Turkey. 4. Ordu University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, Ordu, Turkey.
Abstract
OBJECTIVES: Our study aimed to assess the variation in serum C-reactive protein/albumin ratio (CAR), a biomarker of peripheral inflammation and oxidative stress, in patients with restless legs syndrome (RLS). METHODS: The study included a total of 380 individuals including 197 with RLS diagnosis. RLS diagnosis was determined according to the "International Restless Legs Syndrome Study Group" questionnaire. Disease severity was assessed according to the "International Restless Legs Syndrome Study Group Severity Scale''. RESULTS: The mean age of patients with restless legs syndrome was 52.5 ± 12.7 years, while the mean age in the control group was 50.8 ± 11.2, with no statistically significant difference found (p = 0.156). The hemoglobin, iron and ferritin levels in the patient group were lower than in the control group (p < 0.001; p < 0.01; p < 0.001), with total iron binding capacity levels higher than the control group (p < 0.001). The mean ferritin in the RLS group (49.8 ± 51.2) was lower than the control group (76.9 ± 44.7). In patients, the c-reactive protein, albumin and c-reactive protein/albumin ratio were found to be 0.21 ± 0.18, 4.43 ± 0.31 and 0.07 ± 0.05, respectively. When compared with the control group, the patient group had high c-reactive protein (CRP), CAR and low albumin levels (p < 0.001). Among patients with "very severe" disease severity, ferritin levels were found to be lower than those with "moderate" disease severity. Additionally, patients with "very severe" disease had albumin levels which were significantly low compared to those with "mild" disease severity (p < 0.05). CONCLUSION: Our study supports the hypothesis that serum albumin level, ferritin, CRP, and CAR may be associated with restless legs syndrome.
OBJECTIVES: Our study aimed to assess the variation in serum C-reactive protein/albumin ratio (CAR), a biomarker of peripheral inflammation and oxidative stress, in patients with restless legs syndrome (RLS). METHODS: The study included a total of 380 individuals including 197 with RLS diagnosis. RLS diagnosis was determined according to the "International Restless Legs Syndrome Study Group" questionnaire. Disease severity was assessed according to the "International Restless Legs Syndrome Study Group Severity Scale''. RESULTS: The mean age of patients with restless legs syndrome was 52.5 ± 12.7 years, while the mean age in the control group was 50.8 ± 11.2, with no statistically significant difference found (p = 0.156). The hemoglobin, iron and ferritin levels in the patient group were lower than in the control group (p < 0.001; p < 0.01; p < 0.001), with total iron binding capacity levels higher than the control group (p < 0.001). The mean ferritin in the RLS group (49.8 ± 51.2) was lower than the control group (76.9 ± 44.7). In patients, the c-reactive protein, albumin and c-reactive protein/albumin ratio were found to be 0.21 ± 0.18, 4.43 ± 0.31 and 0.07 ± 0.05, respectively. When compared with the control group, the patient group had high c-reactive protein (CRP), CAR and low albumin levels (p < 0.001). Among patients with "very severe" disease severity, ferritin levels were found to be lower than those with "moderate" disease severity. Additionally, patients with "very severe" disease had albumin levels which were significantly low compared to those with "mild" disease severity (p < 0.05). CONCLUSION: Our study supports the hypothesis that serum albumin level, ferritin, CRP, and CAR may be associated with restless legs syndrome.
Authors: Julia Nowowiejska; Anna Baran; Marta Lewoc; Paulina Grabowska; Tomasz W Kaminski; Iwona Flisiak Journal: J Clin Med Date: 2021-02-09 Impact factor: 4.241
Authors: M Cristina Fernandez-Jimenez; Gemma Moreno; Ione Wright; Pei-Chun Shih; M Pilar Vaquero; Angel F Remacha Journal: Womens Health Rep (New Rochelle) Date: 2020-01-29
Authors: Joseph Dowsett; Maria Didriksen; Margit Hørup Larsen; Khoa Manh Dinh; Kathrine Agergård Kaspersen; Susan Mikkelsen; Lise Wegner Thørner; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Jesper Eugen-Olsen; Karina Banasik; Sisse Rye Ostrowski Journal: PLoS One Date: 2021-11-12 Impact factor: 3.240
Authors: Joseph Dowsett; Maria Didriksen; Jakob Hjorth von Stemann; Margit Hørup Larsen; Lise Wegner Thørner; Erik Sørensen; Christian Erikstrup; Ole Birger Pedersen; Morten Bagge Hansen; Jesper Eugen-Olsen; Karina Banasik; Sisse Rye Ostrowski Journal: Sci Rep Date: 2022-01-31 Impact factor: 4.379