Literature DB >> 31129040

Initiating the T Cell Response to Liver-Stage Malaria.

Komi Gbedande1, Robin Stephens2.   

Abstract

Kurup et al. (Cell Host Microbe 2019;25:565-577.e6) define the liver-based antigen-presenting cell driving CD8 T cell responses to mosquito transmission of Plasmodium spp., and show direct interaction of CD11c+ cells with infected hepatocytes. We discuss this work in context, highlighting gaps and new approaches suggested by the work to target liver-stage vaccine antigens.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  T cell; dendritic cell; liver; malaria

Year:  2019        PMID： 31129040     DOI： 10.1016/j.pt.2019.04.011

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  1 in total

1.  IMRAS-A clinical trial of mosquito-bite immunization with live, radiation-attenuated P. falciparum sporozoites: Impact of immunization parameters on protective efficacy and generation of a repository of immunologic reagents.

Authors:  Bradley Hickey; Nimfa Teneza-Mora; Joanne Lumsden; Sharina Reyes; Martha Sedegah; Lindsey Garver; Michael R Hollingdale; Jo Glenna Banania; Harini Ganeshan; Megan Dowler; Anatalio Reyes; Cindy Tamminga; Alexandra Singer; Alicia Simmons; Maria Belmonte; Arnel Belmonte; Jun Huang; Sandra Inoue; Rachel Velasco; Steve Abot; Carlos S Vasquez; Ivelese Guzman; Mimi Wong; Patrick Twomey; Mariusz Wojnarski; James Moon; Yolanda Alcorta; Santina Maiolatesi; Michele Spring; Silas Davidson; Sidhartha Chaudhury; Eileen Villasante; Thomas L Richie; Judith E Epstein
Journal:  PLoS One       Date:  2020-06-17       Impact factor: 3.240
  1 in total

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