A Surbone1, L Vaucher2, M-P Primi3, C Leyvraz3, N Pitteloud4, P Ballabeni5, P Mathevet6, N Vulliemoz7. 1. Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital, CH-1011 Lausanne, Switzerland. Electronic address: anna.surbone@chuv.ch. 2. Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital, CH-1011 Lausanne, Switzerland; Clinique de Genolier, Route du Muids 3, CH-1272 Genolier, Switzerland. 3. Laboratory of Andrology and Reproductive Biology, Department Woman Mother Child, Lausanne University Hospital, CH-1011 Lausanne, Switzerland. 4. Service of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, Lausanne University Hospital, CH-1011 Lausanne, Switzerland. 5. Institute of Social and Preventive Medicine and Clinical Trial Unit (CRC), Lausanne University Hospital, CH-1011 Lausanne, Switzerland. 6. Service of Gynaecology, Department Woman Mother Child, Lausanne University Hospital, CH-1011 Lausanne, Switzerland. 7. Fertility Medicine and Gynaecological Endocrinology Unit, Department Woman Mother Child, Lausanne University Hospital, CH-1011 Lausanne, Switzerland.
Abstract
OBJECTIVE: To determine the effect of a 3-month course of clomiphene citrate (CC) on plasma testosterone (T) level and on semen parameters in 18 infertile men with low T level and normal or low gonadotropines level. STUDY DESIGN: A retrospective study was conducted by reviewing the medical records of men referred to a university fertility medicine unit for infertility management between January 2010 and March 2015. Men treated with CC for at least 3 months were included if they presented with: RESULTS: 18 patients met the inclusion criteria. CC was prescribed for 3 months at the dose of 50 mg every 48 h. Plasma T level was assessed at baseline and after 1 month of CC administration. Semen parameters were assessed at baseline and after 3 months of CC administration. The median pre-treatment T level was 9.1 nmol/l; after 1 month of CC treatment the median post-treatment T level increased to 20.2 nmol/l (p = <0.001). Median baseline sperm concentration was 7 millions/ml with a median progressive motility of 18%. After 3 months of CC, the median post-treatment sperm concentration was 17.5 millions/ml (p = 0.024) and the median post-treatment progressive sperm motility was 18% (p = 0.40). Three natural pregnancies occurred during the treatment period. CONCLUSION: CC is an effective and inexpensive treatment to increase plasma T level in infertile men with low T level and normal or low gonadotropines level. Our study suggests that CC could increase sperm concentration even in oligospermic infertile men, without, however, a significant effect on progressive sperm motility. More powered randomized controlled trials are needed to definitively assess CC effect on sperm parameters and on natural pregnancy rates.
OBJECTIVE: To determine the effect of a 3-month course of clomiphene citrate (CC) on plasma testosterone (T) level and on semen parameters in 18 infertile men with low T level and normal or low gonadotropines level. STUDY DESIGN: A retrospective study was conducted by reviewing the medical records of men referred to a university fertility medicine unit for infertility management between January 2010 and March 2015. Men treated with CC for at least 3 months were included if they presented with: RESULTS: 18 patients met the inclusion criteria. CC was prescribed for 3 months at the dose of 50 mg every 48 h. Plasma T level was assessed at baseline and after 1 month of CC administration. Semen parameters were assessed at baseline and after 3 months of CC administration. The median pre-treatment T level was 9.1 nmol/l; after 1 month of CC treatment the median post-treatment T level increased to 20.2 nmol/l (p = <0.001). Median baseline sperm concentration was 7 millions/ml with a median progressive motility of 18%. After 3 months of CC, the median post-treatment sperm concentration was 17.5 millions/ml (p = 0.024) and the median post-treatment progressive sperm motility was 18% (p = 0.40). Three natural pregnancies occurred during the treatment period. CONCLUSION: CC is an effective and inexpensive treatment to increase plasma T level in infertile men with low T level and normal or low gonadotropines level. Our study suggests that CC could increase sperm concentration even in oligospermic infertile men, without, however, a significant effect on progressive sperm motility. More powered randomized controlled trials are needed to definitively assess CC effect on sperm parameters and on natural pregnancy rates.
Authors: John M Masterson; Jordan Cohen; Ruben Blachman-Braun; Graham L Machen; Jay Sandlow; Ranjith Ramasamy Journal: Transl Androl Urol Date: 2020-04
Authors: The Son Trinh; Nguyen Ba Hung; Le Thi Thu Hien; Ngo Anh Tuan; Dinh Cong Pho; Quan Anh Dung; Duc Anh Do; Ha Duc Quang; Hoang Van Ai; Pham Ngoc Hung Journal: Res Rep Urol Date: 2021-06-15