Zheng Li1, Xiaohui Xu1, Lindsay A Thompson1, Heather E Gross1, Elizabeth A Shenkman1, Darren A DeWalt1, I-Chan Huang2. 1. College of Nursing and Health Professions, Valparaiso University, Valparaiso, Ind (Z Li); Department of Epidemiology and Statistics, School of Public Health, Texas A&M Health Science Center, College Station (X Xu); Departments of Pediatrics (LA Thompson); Health Outcomes & Biomedical Informatics (EA Shenkman), College of Medicine, University of Florida, Gainesville; Cecil G. Sheps Center for Health Services Research (HE Gross); Department of Medicine, School of Medicine (DA DeWalt), University of North Carolina at Chapel Hill; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tenn (I-C Huang). 2. College of Nursing and Health Professions, Valparaiso University, Valparaiso, Ind (Z Li); Department of Epidemiology and Statistics, School of Public Health, Texas A&M Health Science Center, College Station (X Xu); Departments of Pediatrics (LA Thompson); Health Outcomes & Biomedical Informatics (EA Shenkman), College of Medicine, University of Florida, Gainesville; Cecil G. Sheps Center for Health Services Research (HE Gross); Department of Medicine, School of Medicine (DA DeWalt), University of North Carolina at Chapel Hill; Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tenn (I-C Huang). Electronic address: i-chan.huang@stjude.org.
Abstract
OBJECTIVE: Although exposure to air pollution and pollen is associated with asthma exacerbation and increased health care use, longitudinal effects of fine particulate matter 2.5 (PM2.5), ozone (O3), and pollen exposure on asthma control status in pediatric patients are understudied. This study investigated effects of exposure to PM2.5, O3, and pollen on asthma control status among pediatric patients with asthma. METHODS: A total of 229 dyads of pediatric patients with asthma and their parents were followed for 15 months. The Asthma Control and Communication Instrument was used to measure asthma control, which was reported weekly by parents during a 26-week period. PM2.5 and O3 data were collected from the US Environmental Protection Agency Air Quality System. Pollen data were obtained from Intercontinental Marketing Services Health. Mean air pollutant and pollen exposures within 7 days before the reporting of asthma control were used to estimate weekly exposures for each participant. Linear mixed-effects models were performed to test associations of PM2.5, O3, and pollen exposure with asthma control status. Sensitivity analyses were performed to evaluate the robustness of findings by different exposure monitoring days per week and distances between monitoring sites and participants' residences. RESULTS: Elevated PM2.5 concentration and pollen severity were associated with poorer asthma control status (P < .05), yet elevated O3 concentration was marginally associated with better asthma control (P < .1). CONCLUSIONS: Poorer asthma control status was associated with elevated PM2.5 and pollen severity. Reducing harmful outdoor environmental ambient exposure may improve asthma outcomes in children and adolescents.
OBJECTIVE: Although exposure to air pollution and pollen is associated with asthma exacerbation and increased health care use, longitudinal effects of fine particulate matter 2.5 (PM2.5), ozone (O3), and pollen exposure on asthma control status in pediatric patients are understudied. This study investigated effects of exposure to PM2.5, O3, and pollen on asthma control status among pediatric patients with asthma. METHODS: A total of 229 dyads of pediatric patients with asthma and their parents were followed for 15 months. The Asthma Control and Communication Instrument was used to measure asthma control, which was reported weekly by parents during a 26-week period. PM2.5 and O3 data were collected from the US Environmental Protection Agency Air Quality System. Pollen data were obtained from Intercontinental Marketing Services Health. Mean air pollutant and pollen exposures within 7 days before the reporting of asthma control were used to estimate weekly exposures for each participant. Linear mixed-effects models were performed to test associations of PM2.5, O3, and pollen exposure with asthma control status. Sensitivity analyses were performed to evaluate the robustness of findings by different exposure monitoring days per week and distances between monitoring sites and participants' residences. RESULTS: Elevated PM2.5 concentration and pollen severity were associated with poorer asthma control status (P < .05), yet elevated O3 concentration was marginally associated with better asthma control (P < .1). CONCLUSIONS: Poorer asthma control status was associated with elevated PM2.5 and pollen severity. Reducing harmful outdoor environmental ambient exposure may improve asthma outcomes in children and adolescents.
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