Nihal Saad Elbialy1, Samia Faisal Aboushoushah2, Wafa Wuqayyan Alshammari3. 1. Medical Physics Program, Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Department of Biophysics, Faculty of Science, Cairo University, Egypt. Electronic address: nsmohamad@kau.edu.sa. 2. Medical Physics Program, Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: aboushoushah@kau.edu.sa. 3. Faculty of Applied Medical Science, Hail University, Hail, Saudi Arabia.
Abstract
AIM: In this study, in vivo biodistribution, clearness and toxicity of curcumin capped iron oxide nanoparticles (Cur-IONPs) were addressed in different body organs. MATERIALS AND METHODS: The physicochemical properties of the prepared Cur-IONPs were investigated. Long term (3 weeks) biodistribution, clearness and toxicity were assessed for a single-dose administration of Cur-IONPs (5 mg/kg). The iron content in liver, kidney, spleen and brain was quantified using atomic absorption spectroscopy. Serum biochemical parameters were also measured. KEY FINDINGS: The integrated in vivo results demonstrated that Cur-IONPs was mostly taken up in the liver and spleen reaching its highest levels on days 1 and 2, respectively. In the brain, the results showed significant accumulation of Cur-IONPs between 1 h to 1-day post injection. This represented the successful penetration Cur-IONPs across the blood-brain barrier. Serum biochemical analysis demonstrated a temporal disturbance in the performance of body organs. Also, the body weights showed no alteration throughout the experiment. SIGNIFICANCE: It has been deduced that the promising green synthesized Cur-IONPs as an "All in One" nanoplatform is safe enough to be used in diagnostic and therapeutic purposes.
AIM: In this study, in vivo biodistribution, clearness and toxicity of curcumin capped iron oxide nanoparticles (Cur-IONPs) were addressed in different body organs. MATERIALS AND METHODS: The physicochemical properties of the prepared Cur-IONPs were investigated. Long term (3 weeks) biodistribution, clearness and toxicity were assessed for a single-dose administration of Cur-IONPs (5 mg/kg). The iron content in liver, kidney, spleen and brain was quantified using atomic absorption spectroscopy. Serum biochemical parameters were also measured. KEY FINDINGS: The integrated in vivo results demonstrated that Cur-IONPs was mostly taken up in the liver and spleen reaching its highest levels on days 1 and 2, respectively. In the brain, the results showed significant accumulation of Cur-IONPs between 1 h to 1-day post injection. This represented the successful penetration Cur-IONPs across the blood-brain barrier. Serum biochemical analysis demonstrated a temporal disturbance in the performance of body organs. Also, the body weights showed no alteration throughout the experiment. SIGNIFICANCE: It has been deduced that the promising green synthesized Cur-IONPs as an "All in One" nanoplatform is safe enough to be used in diagnostic and therapeutic purposes.
Authors: Adriana Elena Bulboacă; Paul Mihai Boarescu; Sorana D Bolboacă; Mihai Blidaru; Dana Feștilă; Gabriela Dogaru; Cristina Ariadna Nicula Journal: Int J Nanomedicine Date: 2019-11-18
Authors: Guilherme A Soares; João V C Faria; Leonardo A Pinto; Andre G Prospero; Gabriele M Pereira; Erick G Stoppa; Lais P Buranello; Andris F Bakuzis; Oswaldo Baffa; José R A Miranda Journal: Materials (Basel) Date: 2022-03-14 Impact factor: 3.623