Literature DB >> 31126754

Promises of Nanotherapeutics in Obesity.

Garrett I Ash1, Dongin Kim2, Mahua Choudhury3.   

Abstract

The application of nanotechnology to medicine promises a wide range of new tools and possibilities, from earlier diagnostics and improved imaging, to better, more efficient, and more targeted therapies. This emerging field could help address obesity, with advances in drug delivery, nutraceuticals, and genetic and epigenetic therapeutics. Its application to obesity is still largely in the development phase. Here, we review the novel angle of nanotech applied to human consumable products and their specific applications to addressing obesity through nutraceuticals, with respect to benefits and limitations of current nanotechnology methods. Further, we review potential future applications to deliver genetic and epigenetic miRNA therapeutics. Finally, we discuss future directions, including theranostics, combinatory therapy, and personalized medicine.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  diabetes; epigenetics; gene therapy; miRNA; nanotechnology; obesity

Year:  2019        PMID: 31126754      PMCID: PMC6716370          DOI: 10.1016/j.tem.2019.04.004

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN: 1043-2760            Impact factor:   12.015


  104 in total

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Authors:  Ugo Bilati; Eric Allémann; Eric Doelker
Journal:  Eur J Pharm Sci       Date:  2005-01       Impact factor: 4.384

Review 2.  Paclitaxel poliglumex (XYOTAX, CT-2103): a macromolecular taxane.

Authors:  Jack W Singer
Journal:  J Control Release       Date:  2005-11-16       Impact factor: 9.776

3.  Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery.

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Journal:  Nucleic Acids Symp Ser (Oxf)       Date:  2005

Review 4.  Paclitaxel and its formulations.

Authors:  Anil K Singla; Alka Garg; Deepika Aggarwal
Journal:  Int J Pharm       Date:  2002-03-20       Impact factor: 5.875

Review 5.  Poly(ethylene glycol) (PEG)-mediated fusion between pure lipid bilayers: a mechanism in common with viral fusion and secretory vesicle release?

Authors:  B R Lentz; J K Lee
Journal:  Mol Membr Biol       Date:  1999 Oct-Nov       Impact factor: 2.857

Review 6.  Paclitaxel: a review of adverse toxicities and novel delivery strategies.

Authors:  Neena I Marupudi; James E Han; Khan W Li; Violette M Renard; Betty M Tyler; Henry Brem
Journal:  Expert Opin Drug Saf       Date:  2007-09       Impact factor: 4.250

7.  Reversal of obesity by targeted ablation of adipose tissue.

Authors:  Mikhail G Kolonin; Pradip K Saha; Lawrence Chan; Renata Pasqualini; Wadih Arap
Journal:  Nat Med       Date:  2004-05-09       Impact factor: 53.440

8.  Influence of hydrocolloidal silver nanoparticles on gastrointestinal microflora and morphology of enterocytes of quails.

Authors:  Ewa Sawosz; Marian Binek; Marta Grodzik; Marlena Zielińska; Pawel Sysa; Maciej Szmidt; Tomasz Niemiec; André Chwalibog
Journal:  Arch Anim Nutr       Date:  2007-12       Impact factor: 2.242

9.  Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation.

Authors:  Tao Yang; Fu-De Cui; Min-Koo Choi; Jei-Won Cho; Suk-Jae Chung; Chang-Koo Shim; Dae-Duk Kim
Journal:  Int J Pharm       Date:  2007-02-13       Impact factor: 5.875

10.  Liposome formulation of paclitaxel with enhanced solubility and stability.

Authors:  Tao Yang; Fu-De Cui; Min-Koo Choi; Hongxia Lin; Suk-Jae Chung; Chang-Koo Shim; Dae-Duk Kim
Journal:  Drug Deliv       Date:  2007-07       Impact factor: 6.419

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  3 in total

Review 1.  Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment.

Authors:  Di Huang; Meng Deng; Shihuan Kuang
Journal:  Trends Endocrinol Metab       Date:  2019-10-25       Impact factor: 12.015

2.  MicroRNA loaded edible nanoparticles: an emerging personalized therapeutic approach for the treatment of obesity and metabolic disorders.

Authors:  F Campolo; G Catanzaro; M A Venneri; E Ferretti; Z M Besharat
Journal:  Theranostics       Date:  2022-03-05       Impact factor: 11.600

Review 3.  Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities.

Authors:  Jing Li; Hongli Duan; Yan Liu; Lu Wang; Xing Zhou
Journal:  Pharmaceutics       Date:  2022-07-11       Impact factor: 6.525

  3 in total

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