Literature DB >> 3112610

Free light chains in multiple sclerosis and infections of the CNS.

C DeCarli, M A Menegus, R A Rudick.   

Abstract

The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels of free kappa chains; free kappa:free lambda chain ratio; free kappa chain:albumin ratio; and IgG:albumin ratio. There were no differences in the level of free lambda chains or absolute concentration of IgG. A significant correlation was observed between free kappa chains and total IgG in MS and between free lambda chains and total IgG in infections, suggesting that the immune response was predominantly IgG-kappa in MS and IgG-lambda in infections.

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Year:  1987        PMID： 3112610     DOI： 10.1212/wnl.37.8.1334

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

1.  Quantification of immunoglobulin free light chains in cerebrospinal fluid by nephelometry.

Authors:  Sophie Desplat-Jégo; Lionel Feuillet; Jean Pelletier; Dominique Bernard; André Ali Chérif; José Boucraut
Journal:  J Clin Immunol       Date:  2005-07       Impact factor: 8.317

2.  Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis.

Authors:  Stefan Presslauer; Dejan Milosavljevic; Thomas Brücke; Peter Bayer; Wolfgang Hübl; Walter Hübl
Journal:  J Neurol       Date:  2008-07-17       Impact factor: 4.849

3.  Urine free light chains in SLE: clonal markers of B-cell activity and potential link to in vivo secreted Ig.

Authors:  J E Hopper; J Golbus; C Meyer; G A Ferrer
Journal:  J Clin Immunol       Date:  2000-03       Impact factor: 8.317

4.  Differences in kappa to lambda (kappa:lambda) ratios of serum and urinary free light chains.

Authors:  M Abe; T Goto; M Kosaka; D Wolfenbarger; D T Weiss; A Solomon
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

5.  Experimental allergic encephalomyelitis in the monkey: humoral immunity and blood-brain barrier function.

Authors:  P Gallo; D Cupic; F Bracco; L Krzalic; B Tavolato; L Battistin
Journal:  Ital J Neurol Sci       Date:  1989-12

6.  Detection of oligoclonal IgG kappa and IgG lambda bands in cerebrospinal fluid and serum with Hevylite™ antibodies. comparison with the free light chain oligoclonal pattern.

Authors:  David Zeman; Pavel Hradílek; Zdeněk Svagera; Eva Mojžíšková; Ivana Woznicová; Olga Zapletalová
Journal:  Fluids Barriers CNS       Date:  2012-02-23

7.  Assessment of Intrathecal Free Light Chain Synthesis: Comparison of Different Quantitative Methods with the Detection of Oligoclonal Free Light Chains by Isoelectric Focusing and Affinity-Mediated Immunoblotting.

Authors:  David Zeman; Pavlína Kušnierová; Zdeněk Švagera; František Všianský; Monika Byrtusová; Pavel Hradílek; Barbora Kurková; Olga Zapletalová; Vladimír Bartoš
Journal:  PLoS One       Date:  2016-11-15       Impact factor: 3.240

8.  Free immunoglobulin light chain (FLC) promotes murine colitis and colitis-associated colon carcinogenesis by activating the inflammasome.

Authors:  Junfan Ma; Dongyang Jiang; Xiaoting Gong; Wenwei Shao; Zhu Zhu; Weiyan Xu; Xiaoyan Qiu
Journal:  Sci Rep       Date:  2017-07-12       Impact factor: 4.379

9.  Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

Authors:  C E Leurs; Ham Twaalfhoven; B I Lissenberg-Witte; V van Pesch; I Dujmovic; J Drulovic; M Castellazzi; T Bellini; M Pugliatti; J Kuhle; L M Villar; J C Alvarez-Cermeño; R Alvarez-Lafuente; H Hegen; F Deisenhammer; L M Walchhofer; E Thouvenot; M Comabella; X Montalban; L Vécsei; C Rajda; D Galimberti; E Scarpini; A Altintas; K Rejdak; J L Frederiksen; G Pihl-Jensen; Peh Jensen; M Khalil; M M Voortman; F Fazekas; A Saiz; D La Puma; M Vercammen; L Vanopdenbosch; Bmj Uitdehaag; J Killestein; C Bridel; C Teunissen
Journal:  Mult Scler       Date:  2019-05-08       Impact factor: 6.312

10.  Cerebrospinal fluid immunoglobulin kappa light chain in clinically isolated syndrome and multiple sclerosis.

Authors:  Makbule Senel; Hayrettin Tumani; Florian Lauda; Stefan Presslauer; Rehaneh Mojib-Yezdani; Markus Otto; Johannes Brettschneider
Journal:  PLoS One       Date:  2014-04-02       Impact factor: 3.240
  10 in total

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