Literature DB >> 31125744

Chlorinated paraffins in indoor dust from Australia: Levels, congener patterns and preliminary assessment of human exposure.

Chang He1, Sicco H Brandsma2, Hui Jiang3, Jake W O'Brien3, Louise M van Mourik2, Andrew P Banks3, Xianyu Wang3, Phong K Thai3, Jochen F Mueller3.   

Abstract

Chlorinated paraffins (CPs) are a group of polychlorinated n-alkanes with high production volumes. Until now, there are only limited data on the levels of CPs in the environment, especially in the indoor environment. In this study, dust samples were collected from 44 indoor environments, including 27 private houses, 10 offices, and 7 vehicles. Short-, medium-, and long-chain CPs were detected in all dust samples. The median concentration of ∑CPs (C10-C21) was 57, 160 and 290 μg/g, in houses, offices, and vehicles, respectively. Medium-chain CPs were the dominant group, on average accounting for 86% of ∑CPs. Cl6 and Cl8 groups had the highest contributions to ∑CPs across all the different microenvironments, while C13 and C14 were the predominant groups of SCCPs and MCCPs. Median exposure to ∑CPs via indoor dust were estimated at 80 ng/kg/day and 620 μg/kg/day for Australian adults and toddlers respectively. The daily intake of CPs via dust, in the worse scenario, was still 2-3 orders of magnitudes lower than the reference doses based on neoplastic effects.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Chlorinated paraffins (CPs); Human exposure; Indoor sources; Polychlorinated alkanes (PCAs)

Mesh:

Substances:

Year:  2019        PMID: 31125744     DOI: 10.1016/j.scitotenv.2019.05.170

Source DB:  PubMed          Journal:  Sci Total Environ        ISSN: 0048-9697            Impact factor:   7.963


  2 in total

1.  In vitro human cell-based TTR-TRβ CALUX assay indicates thyroid hormone transport disruption of short-chain, medium-chain, and long-chain chlorinated paraffins.

Authors:  Jannik Sprengel; Peter A Behnisch; Harrie Besselink; Abraham Brouwer; Walter Vetter
Journal:  Arch Toxicol       Date:  2021-02-08       Impact factor: 5.153

Review 2.  Status of short-chain chlorinated paraffins in matrices and research gap priorities in Africa: a review.

Authors:  Vhodaho Nevondo; Okechukwu Jonathan Okonkwo
Journal:  Environ Sci Pollut Res Int       Date:  2021-09-03       Impact factor: 4.223

  2 in total

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