Alessio Adamiano1, Victoria M Wu2, Francesca Carella1, Gianrico Lamura3, Fabio Canepa3,4, Anna Tampieri1, Michele Iafisco1, Vuk Uskoković2,5. 1. Institute of Science & Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy. 2. Department of Biomedical & Pharmaceutical Sciences, Center for Targeted Drug Delivery, Chapman University, Irvine, CA 92618-1908, USA. 3. Institute of Superconductors, Oxides & Other Innovative Materials & Devices (SPIN), National Research Council (CNR), Corso Perrone 24, 16152 Genova, Italy. 4. Department of Chemistry & Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy. 5. Department of Bioengineering, University of Illinois, Chicago, IL 60607-7052, USA.
Abstract
Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.
Aim: Magnetic hyperthermia is limited by the low selective susceptibility of neoplastic cells interspersed within healthy tissues, which we aim to improve on. Materials & methods: Two superparamagnetic calcium phosphates nanocomposites, that is, iron-doped hydroxyapatite and iron oxide (Mag) nanoparticles coated with amorphous calcium phosphate (Mag@CaP), were synthesized and tested for selective activity against brain and bone cancers. Results: Nanoparticle uptake and intracellular localization were prerequisites for reduction of cancer viability in alternate magnetic fields of extremely low power. Sheer adsorption onto the outer membrane was not sufficient to produce this effect, which was extremely significant for Mag@CaP and iron-doped hydroxyapatite, but negligible for Mag, demonstrating benefits of combining magnetic iron with calcium phosphates. Conclusion: Such selective effects are important in the global effort to rejuvenate clinical prospects of magnetic hyperthermia.
Entities:
Keywords:
calcium phosphate; composite nanoparticles; glioblastoma; magnetic hyperthermia; nanoparticles; osteosarcoma
Authors: Georgios P Skandalakis; Daniel R Rivera; Caroline D Rizea; Alexandros Bouras; Joe Gerald Jesu Raj; Dominique Bozec; Constantinos G Hadjipanayis Journal: Int J Hyperthermia Date: 2020-07 Impact factor: 3.914
Authors: Tiê Menezes Oliveira; Fernanda Costa Brandão Berti; Sidney Carlos Gasoto; Bertoldo Schneider; Marco Augusto Stimamiglio; Lucas Freitas Berti Journal: Front Med Technol Date: 2021-06-30