INTRODUCTION: Sarcopenia is highly prevalent in patients with gastrointestinal malignancies, including gastric cancer, but there is a lack of adequate data from Western populations. METHODS: Computed tomography scans of 138 Caucasian patients subject to stomach resections due to gastric adenocarcinoma between 2012 and 2015 were reviewed to evaluate the impact of sarcopenia. The definition of sarcopenia was based on the lumbar skeletal muscle index (SMI) using cut-off values formulated by the international consensus definitions of sarcopenia (SMI <52.4 cm2 /m2 for men and <38.5 cm2 /m2 for women). RESULTS: Sixty (43%) of 138 patients were sarcopenic. Sarcopenia was associated with postoperative morbidity (43% vs 23%; P = .011), major postoperative complications (Clavien-Dindo ≥3a; 36% vs 21%; P = .035), and reoperations (23% vs 9%; P = .020). Patients with sarcopenia also had prolonged postoperative hospital stay (8.0 vs 6.5 days; P = .010). The overall median survival of patients with sarcopenia was significantly lower than those with normal skeletal muscles (11.0 vs 36.7 months; P = .005) and sarcopenia remained an independent prognostic factor with an odds ratio of 1.94 (95% confidence interval, 1.08 to 3.48; P = .026). CONCLUSION: Sarcopenia, defined by SMI, is associated with an increased risk of postoperative morbidity and impaired long-term survival.
INTRODUCTION:Sarcopenia is highly prevalent in patients with gastrointestinal malignancies, including gastric cancer, but there is a lack of adequate data from Western populations. METHODS: Computed tomography scans of 138 Caucasian patients subject to stomach resections due to gastric adenocarcinoma between 2012 and 2015 were reviewed to evaluate the impact of sarcopenia. The definition of sarcopenia was based on the lumbar skeletal muscle index (SMI) using cut-off values formulated by the international consensus definitions of sarcopenia (SMI <52.4 cm2 /m2 for men and <38.5 cm2 /m2 for women). RESULTS: Sixty (43%) of 138 patients were sarcopenic. Sarcopenia was associated with postoperative morbidity (43% vs 23%; P = .011), major postoperative complications (Clavien-Dindo ≥3a; 36% vs 21%; P = .035), and reoperations (23% vs 9%; P = .020). Patients with sarcopenia also had prolonged postoperative hospital stay (8.0 vs 6.5 days; P = .010). The overall median survival of patients with sarcopenia was significantly lower than those with normal skeletal muscles (11.0 vs 36.7 months; P = .005) and sarcopenia remained an independent prognostic factor with an odds ratio of 1.94 (95% confidence interval, 1.08 to 3.48; P = .026). CONCLUSION:Sarcopenia, defined by SMI, is associated with an increased risk of postoperative morbidity and impaired long-term survival.
Authors: Lucy X Ma; Kirsty Taylor; Osvaldo Espin-Garcia; Reut Anconina; Chihiro Suzuki; Michael J Allen; Marta Honorio; Yvonne Bach; Frances Allison; Eric X Chen; Savtaj Brar; Carol J Swallow; Jonathan Yeung; Gail E Darling; Rebecca Wong; Sangeetha N Kalimuthu; Raymond W Jang; Patrick Veit-Haibach; Elena Elimova Journal: Cancer Med Date: 2020-12-09 Impact factor: 4.452
Authors: Thaís T T Tweed; Arjen van der Veen; Stan Tummers; David P J van Dijk; Misha D P Luyer; Jelle P Ruurda; Richard van Hillegersberg; Jan H M B Stoot; Juul J W Tegels; Karel W E Hulsewe; Hylke J F Brenkman; Maarten F J Seesing; Grard A P Nieuwenhuijzen; Jeroen E H Ponten; Bas P L Wijnhoven; Sjoerd M Lagarde; Wobbe O de Steur; Henk H Hartgrink; Ewout A Kouwenhoven; Marc J van Det; Eelco B Wassenaar; Edwin S van der Zaag; Werner A Draaisma; Ivo A M J Broeders; Suzanne S Gisbertz; Mark I van Berge Henegouwen; Hanneke W M van Laarhoven Journal: J Gastrointest Surg Date: 2022-04-29 Impact factor: 3.267
Authors: Alicia S Borggreve; Robin B den Boer; Gijs I van Boxel; Pim A de Jong; Wouter B Veldhuis; Elles Steenhagen; Richard van Hillegersberg; Jelle P Ruurda Journal: J Clin Med Date: 2020-01-11 Impact factor: 4.241