Thomas J van Rijssen1, Elon H C van Dijk1, Paula Scholz2, Myrte B Breukink3, Rocio Blanco-Garavito4, Eric H Souied4, Robert E MacLaren5, Giuseppe Querques4,6, Sascha Fauser2,7, Carel B Hoyng3, Susan M Downes5, Camiel J F Boon8,9. 1. Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. 2. Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany. 3. Department of Ophthalmology, Radboud University Medical Center, Nijmegen, The Netherlands. 4. Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Paris, France. 5. Oxford Eye Hospital, John Radcliffe Hospital, West Wing, Oxford, UK. 6. Department of Ophthalmology, IRCCS Ospedale San Raffaele, Vita-Salute University, Milan, Italy. 7. F. Hoffmann-La Roche, Basel, Switzerland. 8. Department of Ophthalmology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. c.j.f.boon@lumc.nl. 9. Amsterdam University Medical Center, Department of Ophthalmology, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands. c.j.f.boon@lumc.nl.
Abstract
PURPOSE: To describe the characteristics and potential differences between focal and diffuse phenotypes of untreated chronic central serous chorioretinopathy (cCSC). METHODS: For this study, patients were divided in two groups. Focal leakage was defined as 1 "hot spot" of leakage, whereas diffuse leakage was defined as either > 1 hot spot or a larger area of widespread leakage on FA. Clinical characteristics were assessed at presentation. After Bonferroni correction, P values < 0.00125 were deemed statistically significant. RESULTS: The focal leakage group included 68 eyes (53 males), and the diffuse leakage group included 105 eyes (88 males). Mean best-corrected visual acuity (BCVA) was 77.1 ± 8.1 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the focal group and 76.0 ± 9.6 ETDRS letters in the diffuse group (p = 0.440). In the focal group, mean age was 46.9 ± 8.8 years, whereas this was 49.7 ± 8.3 years in the diffuse group (p = 0.033). Mean central foveal thickness was 107.1 ± 21.3 μm in the focal group and 106.2 ± 27.3 μm in the diffuse group (p = 0.818). Mean choroidal thickness was 407.5 ± 114.8 μm in the focal group and 419.1 ± 113.9 μm in the diffuse group (p = 0.578). In the focal group, subretinal fluid was present in the fellow eye in 16% of the patients, as compared to 29% in the diffuse group (p = 0.067). CONCLUSIONS: In untreated cCSC patients with focal or diffuse leakage on FA, no marked differences in clinical characteristics were found. Extensive choroidal abnormalities may be present in both groups, which are presumed to lie at the basis of the development of cCSC.
PURPOSE: To describe the characteristics and potential differences between focal and diffuse phenotypes of untreated chronic central serous chorioretinopathy (cCSC). METHODS: For this study, patients were divided in two groups. Focal leakage was defined as 1 "hot spot" of leakage, whereas diffuse leakage was defined as either > 1 hot spot or a larger area of widespread leakage on FA. Clinical characteristics were assessed at presentation. After Bonferroni correction, P values < 0.00125 were deemed statistically significant. RESULTS: The focal leakage group included 68 eyes (53 males), and the diffuse leakage group included 105 eyes (88 males). Mean best-corrected visual acuity (BCVA) was 77.1 ± 8.1 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the focal group and 76.0 ± 9.6 ETDRS letters in the diffuse group (p = 0.440). In the focal group, mean age was 46.9 ± 8.8 years, whereas this was 49.7 ± 8.3 years in the diffuse group (p = 0.033). Mean central foveal thickness was 107.1 ± 21.3 μm in the focal group and 106.2 ± 27.3 μm in the diffuse group (p = 0.818). Mean choroidal thickness was 407.5 ± 114.8 μm in the focal group and 419.1 ± 113.9 μm in the diffuse group (p = 0.578). In the focal group, subretinal fluid was present in the fellow eye in 16% of the patients, as compared to 29% in the diffuse group (p = 0.067). CONCLUSIONS: In untreated cCSC patients with focal or diffuse leakage on FA, no marked differences in clinical characteristics were found. Extensive choroidal abnormalities may be present in both groups, which are presumed to lie at the basis of the development of cCSC.
Entities:
Keywords:
Central serous chorioretinopathy; Diffuse leakage; Fluorescein angiography; Focal leakage; Indocyanine green angiography
Authors: Thomas J van Rijssen; Elon H C van Dijk; Paula Scholz; Robert E MacLaren; Sascha Fauser; Susan M Downes; Carel B Hoyng; Camiel J F Boon Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-10-29 Impact factor: 3.117
Authors: Thomas J van Rijssen; Elon H C van Dijk; Paula Scholz; Myrte B Breukink; Greet Dijkman; Petrus J H Peters; Roula Tsonaka; Jan E E Keunen; Robert E MacLaren; Carel B Hoyng; Susan M Downes; Sascha Fauser; Camiel J F Boon Journal: Acta Ophthalmol Date: 2021-02-10 Impact factor: 3.761