Kehong Fang1, Yuna He1, Min Mu2, Kai Liu3. 1. Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, China. 2. College of Medicine, Anhui University of Science and Technology Huainan, China. 3. Chinese Center for Disease Control and Prevention, National Institute of Occupation Health an Poison Control, Beijing, China.
Abstract
OBJECTIVE: The object of the present study was to estimate the relationship between maternal vitamin D deficiency during pregnancy and low birth weight by systematically review prevalence studies. METHODS: We collected data from relevant studies published up to April 2019 using predefined inclusion/exclusion criteria. And all the studies were searched in PubMed, Embase, Cochrane Library, and Web of Science. RESULTS: A total of 16 studies met the criteria and were included in the meta-analysis. When compared with normal serum levels of vitamin D, the maternal vitamin D deficiency had an increased risk of low birth weight (OR = 2.39; 95%CI 1.25-4.57; p = .008), and same results were found in the comparison of the mean (the total mean birth weight decreased by 0.08 kg; 95%CI -0.10 to -0.06; p < .001). CONCLUSION: The evidence from this meta-analysis indicates a consistent association between vitamin D deficiency during pregnancy and an increased risk of low birth weight, and preventing maternal vitamin D deficiency may be an important public health strategy to help decrease the risk of low birth weight.
OBJECTIVE: The object of the present study was to estimate the relationship between maternal vitamin D deficiency during pregnancy and low birth weight by systematically review prevalence studies. METHODS: We collected data from relevant studies published up to April 2019 using predefined inclusion/exclusion criteria. And all the studies were searched in PubMed, Embase, Cochrane Library, and Web of Science. RESULTS: A total of 16 studies met the criteria and were included in the meta-analysis. When compared with normal serum levels of vitamin D, the maternal vitamin D deficiency had an increased risk of low birth weight (OR = 2.39; 95%CI 1.25-4.57; p = .008), and same results were found in the comparison of the mean (the total mean birth weight decreased by 0.08 kg; 95%CI -0.10 to -0.06; p < .001). CONCLUSION: The evidence from this meta-analysis indicates a consistent association between vitamin D deficiency during pregnancy and an increased risk of low birth weight, and preventing maternal vitamin D deficiency may be an important public health strategy to help decrease the risk of low birth weight.
Entities:
Keywords:
Low birth weight; meta-analysis; pregnancy; vitamin D deficiency
Authors: Anne Cc Lee; Sara Cherkerzian; Ingrid E Olson; Salahuddin Ahmed; Nabidul Haque Chowdhury; Rasheda Khanam; Sayedur Rahman; Chloe Andrews; Abdullah H Baqui; Wafaie Fawzi; Terrie E Inder; Stephanie Nartey; Charles A Nelson; Emily Oken; Sarbattama Sen; Raina Fichorova Journal: Nutrients Date: 2021-10-26 Impact factor: 5.717