| Literature DB >> 31121284 |
Lucian Del Fabbro1, André Rossito Goes1, Cristiano Ricardo Jesse1, Marcelo Gomes de Gomes2, Leandro Cattelan Souza1, Fernando V Lobo Ladd3, Aliny A B Lobo Ladd4, Ricardo Vinicius Nunes Arantes5, Astor Reis Simionato6, Mauro Schneider Oliveira7, Ana Flavia Furian8, Silvana Peterini Boeira1.
Abstract
Parkinson's disease (PD) is an age-related neurodegenerative disorder that severely affects quality of life of patients and their families. The flavonoid chrysin (5,7-dihydroxylflavone) is a naturally occurring flavone with several pharmacological activities, including anti-inflammatory and anti-oxidative. We investigated the effects of a 28-day chrysin treatment (10 mg/kg/day, i.g.) on a model of PD induced by 6-OHDA in aged (20-month old) mice. We found a protective effect of chrysin on behavioral and cognitive alterations (rotational behavior, passive avoidance and Barnes maze tests), nitric oxide synthesis (NOx), lipid peroxidation (HNE), glutathione levels (GSH), reactive species levels (RS), neuroinflammation (interleukin-1 beta - IL-1β and tumor necrosis factor alpha - TNF-α), Na+, K+-ATPase and nicotinamide adenine dinucleotide phosphate oxidase activity (NADPH oxidase) activities. In addition, chrysin protected against changes in striatal dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels. In conclusion, chrysin improved several behavioral, cognitive and neurochemical parameters in a relevant preclinical model of PD in aged mice.Entities:
Keywords: Behavior; Dopaminergic neurons; Neuroinflammation; Old-mice; Oxidative stress
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Year: 2019 PMID： 31121284 DOI： 10.1016/j.neulet.2019.05.036
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046