Literature DB >> 31121276

Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eye therapeutics.

Whuisu Shim1, Chae Eun Kim2, Mihyun Lee3, Soo Hyeon Lee1, Joseph Park1, Minjae Do1, Jaewook Yang4, Haeshin Lee5.   

Abstract

Catechin exhibits various pharmacological effects, yet its poor aqueous solubility limits its clinical use. Here, we investigate a facile catechin solubilization method via spontaneous hydrogen bonding between catechin and poly(ethylene glycol) (PEG). The method is extremely simple in that mixing PEG with catechin followed by lyophilization completely converts insoluble catechin to soluble PEG/catechin nanoscale complexes. This solubilized catechin formulation is useful for preparing eyedrop medicine, and we demonstrate that the solubilized catechin exhibits therapeutic effect upon dry eye diseases.
Copyright © 2019. Published by Elsevier B.V.

Entities:  

Keywords:  Catechin; Catechol; Hydrogen bond; Poly(ethylene glycol) (PEG); Polyphenol

Year:  2019        PMID： 31121276     DOI： 10.1016/j.jconrel.2019.04.016

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  6 in total

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  6 in total

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