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Literature DB >> 3112094

Comparative in-vitro activity of five fluoroquinolones against mycobacteria.

Abstract

Fifty distinct strains of mycobacteria were investigated to determine their in-vitro susceptibility to five new fluoroquinolones (norfloxacin, pefloxacin, ofloxacin, enoxacin and ciprofloxacin). Ofloxacin and ciprofloxacin were found to be the most active, with minimum inhibitory concentrations (MIC) of 1.25 mg/l or less to all strains of Mycobacterium tuberculosis, M. bovis, M. xenopi, M. kansasii and BCG tested. All agents showed little activity against M. malmoense and M. avium-intracellulare complex with MIC values of greater than 2.5 mg/l.

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Year: 1987 PMID： 3112094 DOI： 10.1093/jac/19.5.605

Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790

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Cited

13 in total

Review 1. Mycobacteria and the new quinolones.

Authors: D C Leysen; A Haemers; S R Pattyn
Journal: Antimicrob Agents Chemother Date: 1989-01 Impact factor: 5.191

2. Antimycobacterial spectrum of sparfloxacin and its activities alone and in association with other drugs against Mycobacterium avium complex growing extracellularly and intracellularly in murine and human macrophages.

Authors: N Rastogi; V Labrousse; K S Goh; J P De Sousa
Journal: Antimicrob Agents Chemother Date: 1991-12 Impact factor: 5.191

8. In vitro activity of the new difluorinated quinolone sparfloxacin (AT-4140) against Mycobacterium tuberculosis compared with activities of ofloxacin and ciprofloxacin.

Authors: N Rastogi; K S Goh
Journal: Antimicrob Agents Chemother Date: 1991-09 Impact factor: 5.191

Review 9. Quinolone disposition in the elderly. Practical implications.

Authors: I Nilsson-Ehle; B Ljungberg
Journal: Drugs Aging Date: 1991 Jul-Aug Impact factor: 3.923

10. Intracellular accumulation of norfloxacin in Mycobacterium smegmatis.

Authors: S Corti; J Chevalier; A Cremieux
Journal: Antimicrob Agents Chemother Date: 1995-11 Impact factor: 5.191

Comparative in-vitro activity of five fluoroquinolones against mycobacteria.

Review 1. Mycobacteria and the new quinolones.

2. Antimycobacterial spectrum of sparfloxacin and its activities alone and in association with other drugs against Mycobacterium avium complex growing extracellularly and intracellularly in murine and human macrophages.

3. MICs and MBCs of Win 57273 against Mycobacterium avium and M. tuberculosis.

Review 4. Enoxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

5. Lesser known mycobacteria.

Review 6. Pefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

7. Susceptibility of Mycobacterium kansasii to ofloxacin, sparfloxacin, clarithromycin, azithromycin, and fusidic acid.

8. In vitro activity of the new difluorinated quinolone sparfloxacin (AT-4140) against Mycobacterium tuberculosis compared with activities of ofloxacin and ciprofloxacin.

Review 9. Quinolone disposition in the elderly. Practical implications.

10. Intracellular accumulation of norfloxacin in Mycobacterium smegmatis.