Stefano Partelli1,2, Fabio Giannone1, Marco Schiavo Lena3, Francesca Muffatti1,2, Valentina Andreasi1,2, Stefano Crippa1,2, Domenico Tamburrino1, Giuseppe Zamboni4, Corrado Rubini5, Claudio Doglioni3,2, Massimo Falconi6,7. 1. Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy. 2. Vita e Salute University, Milan, Italy. 3. Pathology Department, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy. 4. Department of Pathology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy. 5. Department of Pathology, Polytechnic University of the Marche Region, Ancona, Italy. 6. Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy, falconi.massimo@hsr.it. 7. Vita e Salute University, Milan, Italy, falconi.massimo@hsr.it.
Abstract
BACKGROUND/AIMS: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. METHODS: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. RESULTS: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter <5 mm (microadenoma), whereas the other 12 (29%) had a maximum size ≥5 mm (median diameter of the whole series = 3 mm, range 1-15). The association with a main diagnosis of intraductal papillary mucinous neoplasms (IPMN) was significantly higher for patients who had an incidental PanNET (p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. CONCLUSIONS: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.
BACKGROUND/AIMS: The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. The aim of this study was to determine the frequency of incidental histological diagnosis of PanNET in pancreatic specimen evaluation for a purpose other other than PanNET diagnosis. METHODS: One thousand seventy-four histopathological examinations of pancreatic specimens performed in 3 centers in Italy were retrospectively reviewed. All cases with a main pathological diagnosis of PanNET were excluded. RESULTS: An incidental associated diagnosis of PanNET was made in 41 specimens (4%). Among those 41 cases, 29 (71%) had a largest diameter <5 mm (microadenoma), whereas the other 12 (29%) had a maximum size ≥5 mm (median diameter of the whole series = 3 mm, range 1-15). The association with a main diagnosis of intraductal papillary mucinous neoplasms (IPMN) was significantly higher for patients who had an incidental PanNET (p = 0.048). There was no association between incidental diagnosis of PanNET and age, gender, BMI, smoking habit, diabetes, and type of operation. CONCLUSIONS: The frequency of incidental histological diagnosis of PanNET is considerably high, suggesting that their real prevalence is probably underestimated. The present study suggests a possible correlation between the incidental occurrence of PanNET and IPMN.
Authors: F Panzuto; M Maccauro; D Campana; A Faggiano; S Massironi; S Pusceddu; F Spada; D Ferone; R Modica; C M Grana; P Ferolla; M Rinzivillo; G Badalamenti; M C Zatelli; F Gelsomino; E De Carlo; M Bartolomei; M P Brizzi; S Cingarlini; A Versari; G Fanciulli; E Arvat; E Merola; M Cives; S Tafuto; S Baldari; M Falconi Journal: J Endocrinol Invest Date: 2020-08-16 Impact factor: 4.256