Xiaobo Zhou1, Di Sun1, Yang Liu2, Qilin Sun2, Zhaoqi Yuan1, Xusong Luo1, Jun Yang1, Jun Chen2. 1. a Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai JiaoTong University School of Medicine, Center for Specialty Strategy Research of Shanghai JiaoTong University China Hospital Development Institute , Shanghai , PR China. 2. b Department of Dermatology and Dermatologic Surgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai JiaoTong University School of Medicine , Center for Specialty Strategy Research of Shanghai JiaoTong University China Hospital Development Institute , Shanghai , PR China.
Abstract
Background: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma. Its high recurrence rate is a clinical challenge. Objective: To analyze DFSP clinicopathologic factors and review our experience of treatments. Materials and methods: A total of 80 patients who were treated between 2007 and 2017 in Shanghai Ninth People's Hospital were evaluated. Outcomes were compared focusing on recurrence following different treatment methods. Classical DFSP and transformed DFSP were classified as the two subtypes. Results: The recurrence rate after local excision was significantly higher than that after wide margin excision. Patients undergoing wide margin excision (margins over 3 cm) were found to have lower recurrence rate compared with those margins less than 3 cm, while 10 underwent Mohs surgery were not found recurrence. Transformed DFSP had a greater tendency to recur. Conclusions: Clean margin of excision should be achieved to prevent recurrence of DFSP. Slow Mohs surgery is recommended to treat DFSP.
Background: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma. Its high recurrence rate is a clinical challenge. Objective: To analyze DFSP clinicopathologic factors and review our experience of treatments. Materials and methods: A total of 80 patients who were treated between 2007 and 2017 in Shanghai Ninth People's Hospital were evaluated. Outcomes were compared focusing on recurrence following different treatment methods. Classical DFSP and transformed DFSP were classified as the two subtypes. Results: The recurrence rate after local excision was significantly higher than that after wide margin excision. Patients undergoing wide margin excision (margins over 3 cm) were found to have lower recurrence rate compared with those margins less than 3 cm, while 10 underwent Mohs surgery were not found recurrence. Transformed DFSP had a greater tendency to recur. Conclusions: Clean margin of excision should be achieved to prevent recurrence of DFSP. Slow Mohs surgery is recommended to treat DFSP.
Entities:
Keywords:
DFSP; dermatological surgery; skin cancer
Authors: Marjorie Parker David; Ashley Funderburg; James P Selig; Rebecca Brown; Pip M Caliskan; Lee Cove; Gayle Dicker; Lori Hoffman; Tammi Horne; Jerad M Gardner Journal: JAMA Netw Open Date: 2019-08-02
Authors: Jian-Xia Xiong; Tao Cai; Li Hu; Xiao-Li Chen; Kun Huang; Ai-Jun Chen; Ping Wang Journal: World J Clin Cases Date: 2021-07-16 Impact factor: 1.337