Huei-Chen Lin1,2, Ling-Ling Chiang3, Jun-Hui Ong4, Kun-Ling Tsai4, Ching-Hsia Hung1,4, Cheng-Yu Lin5,6,7. 1. Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan. 2. Department of Physical Therapy, Shu-Zen Junior College of Medicine and Management, No.452, Huanqiu Rd. Luzhu Dist., Kaohsiung City, 82144, Taiwan. 3. School of Respiratory Therapy, Taipei Medical University, No. 250 Wuxing St., Taipei, 11031, Taiwan. 4. Department of Physical Therapy, College of Medicine, National Cheng Kung University, No.1, Daxue Rd., East Dist., Tainan City, 70101, Taiwan. 5. Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd., North Dist., Tainan City, 70403, Taiwan. yu621109@ms48.hinet.net. 6. Department of Environmental and Occupational Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Shengli Rd., North Dist., Tainan City, 70403, Taiwan. yu621109@ms48.hinet.net. 7. Department of Otolaryngology, Tainan Hospital, Ministry of Health and Welfare, No.125, Zhongshan Rd., West Central Dist., Tainan City, 70043, Taiwan. yu621109@ms48.hinet.net.
Abstract
OBJECTIVES:Patients with obstructive sleep apnea (OSA) (an obstructed airway and intermittent hypoxia) negatively affect their respiratory muscles. We evaluated the effects of a 12-week threshold inspiratory muscle training (TIMT) program on OSA severity, daytime sleepiness, and pulmonary function in newly diagnosed OSA. METHODS:Sixteen patients with moderate-to-severe OSA were randomly assigned to a TIMT group and 6 to a control group. The home-based TIMT program was 30-45 min/day, 5 days/week, for 12 weeks using a TIMT training device. Their apnea-hypopnea index (AHI), Epworth sleepiness scale (ESS), and forced vital capacity (FVC) scores were evaluated pre- and post-treatment. Polysomnographic (PSG) analysis showed that 9 TIMT-group patients had positively responded (TIMT-responder group: post-treatment AHI < pre-treatment) and that 7 had not (TIMT non-responder group: post-treatment AHI > pre-treatment). RESULTS: Post-treatment AHI and ESS scores were significantly (both P < 0.05) lower 6% and 20.2%, respectively. A baseline AHI ≤ 29.0/h predicted TIMT-responder group patients (sensitivity 77.8%; specificity 85.7%). FVC was also significantly (P < 0.05) higher 7.2%. Baseline AHI and FEV6.0 were significant predictors of successful TIMT-responder group intervention. OSA severity and daytime sleepiness were also significantly attenuated. CONCLUSIONS:Home-based TIMT training is simple, efficacious, and cost-effective.
RCT Entities:
OBJECTIVES:Patients with obstructive sleep apnea (OSA) (an obstructed airway and intermittent hypoxia) negatively affect their respiratory muscles. We evaluated the effects of a 12-week threshold inspiratory muscle training (TIMT) program on OSA severity, daytime sleepiness, and pulmonary function in newly diagnosed OSA. METHODS: Sixteen patients with moderate-to-severe OSA were randomly assigned to a TIMT group and 6 to a control group. The home-based TIMT program was 30-45 min/day, 5 days/week, for 12 weeks using a TIMT training device. Their apnea-hypopnea index (AHI), Epworth sleepiness scale (ESS), and forced vital capacity (FVC) scores were evaluated pre- and post-treatment. Polysomnographic (PSG) analysis showed that 9 TIMT-group patients had positively responded (TIMT-responder group: post-treatment AHI < pre-treatment) and that 7 had not (TIMT non-responder group: post-treatment AHI > pre-treatment). RESULTS: Post-treatment AHI and ESS scores were significantly (both P < 0.05) lower 6% and 20.2%, respectively. A baseline AHI ≤ 29.0/h predicted TIMT-responder group patients (sensitivity 77.8%; specificity 85.7%). FVC was also significantly (P < 0.05) higher 7.2%. Baseline AHI and FEV6.0 were significant predictors of successful TIMT-responder group intervention. OSA severity and daytime sleepiness were also significantly attenuated. CONCLUSIONS: Home-based TIMT training is simple, efficacious, and cost-effective.
Authors: M Mjid; Y Ouahchi; S Toujani; H Snen; N Ben Salah; A Ben Hmida; B Louzir; N Mhiri; J Cherif; M Beji Journal: Rev Mal Respir Date: 2016-05-11 Impact factor: 0.622
Authors: José Carlos Nogueira Nóbrega-Júnior; Armèle Dornelas de Andrade; Erika Alves Marinho de Andrade; Maria do Amparo Andrade; Alice Santana Valadares Ribeiro; Rodrigo Pinto Pedrosa; Ana Paula de Lima Ferreira; Anna Myrna Jaguaribe de Lima Journal: Nat Sci Sleep Date: 2020-12-02
Authors: L M de Azeredo; L C de Souza; B L S Guimarães; F P Puga; N S C S Behrens; J R Lugon Journal: Braz J Med Biol Res Date: 2022-10-03 Impact factor: 2.904