Janett Barbaresko1,2, Johanna Rienks3,4, Kolade Oluwagbemigun3, Gunnar Jacobs5,6, Wolfgang Lieb5,6, Matthias Laudes7, Ute Nöthlings3. 1. Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany. janett.barbaresko@ddz.de. 2. Institute for Biometry and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. janett.barbaresko@ddz.de. 3. Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany. 4. LifeLines Cohort Study, Groningen, The Netherlands. 5. PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany. 6. Institute of Epidemiology, Christian Albrecht University, University Hospital Schleswig-Holstein, Kiel, Germany. 7. Department of General Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
Abstract
PURPOSE: The aim of the present study was to derive overall and sex-specific dietary patterns associated with inflammatory biomarkers in a general population sample from Northern Germany. METHODS: The present analysis included 1158 participants (477 men, 681 women, mean age: 53.1 years; mean body mass index: 26.2 kg/m2) of the Food Chain Plus (FoCus) cohort in Kiel, Germany. Participants completed a semi-quantitative food frequency questionnaire and provided blood samples. Reduced rank regression with C-reactive protein (CRP) and Interleukin 6 (IL-6) as response variables was used to derive dietary patterns. After a mean follow-up of 1.7 years, a second blood sample was obtained in a subsample of 112 individuals. Multiple regression models were used to examine the association between dietary patterns at baseline and inflammatory biomarkers at follow-up. RESULTS: The overall pattern characterised by high intakes of soft drinks, meat, potatoes and sauce, and low intakes of other cereals (except pasta/rice), wine, nuts, seeds, vegetarian dishes, vegetable oil, and fish was positively associated with CRP (OR 2.20; 95% CI 1.12, 4.35) and IL-6 (OR 3.14; 95% CI 1.26, 7.87) at follow-up. In men, the dietary pattern was higher in soft drinks, processed meat and low in cereals and plant-based fats. In women, the pattern was characterised by soft drinks, meat, vegetables and low in other cereals, wine, nuts, and seeds. The association between sex-specific patterns with inflammatory biomarkers was weaker for CRP. CONCLUSION: We identified dietary patterns positively associated with established biomarkers of chronic low-grade inflammation.
PURPOSE: The aim of the present study was to derive overall and sex-specific dietary patterns associated with inflammatory biomarkers in a general population sample from Northern Germany. METHODS: The present analysis included 1158 participants (477 men, 681 women, mean age: 53.1 years; mean body mass index: 26.2 kg/m2) of the Food Chain Plus (FoCus) cohort in Kiel, Germany. Participants completed a semi-quantitative food frequency questionnaire and provided blood samples. Reduced rank regression with C-reactive protein (CRP) and Interleukin 6 (IL-6) as response variables was used to derive dietary patterns. After a mean follow-up of 1.7 years, a second blood sample was obtained in a subsample of 112 individuals. Multiple regression models were used to examine the association between dietary patterns at baseline and inflammatory biomarkers at follow-up. RESULTS: The overall pattern characterised by high intakes of soft drinks, meat, potatoes and sauce, and low intakes of other cereals (except pasta/rice), wine, nuts, seeds, vegetarian dishes, vegetable oil, and fish was positively associated with CRP (OR 2.20; 95% CI 1.12, 4.35) and IL-6 (OR 3.14; 95% CI 1.26, 7.87) at follow-up. In men, the dietary pattern was higher in soft drinks, processed meat and low in cereals and plant-based fats. In women, the pattern was characterised by soft drinks, meat, vegetables and low in other cereals, wine, nuts, and seeds. The association between sex-specific patterns with inflammatory biomarkers was weaker for CRP. CONCLUSION: We identified dietary patterns positively associated with established biomarkers of chronic low-grade inflammation.
Authors: Corinna Geisler; Kristina Schlicht; Carina Knappe; Nathalie Rohmann; Katharina Hartmann; Kathrin Türk; Ute Settgast; Dominik M Schulte; Tobias Demetrowitsch; Julia Jensen-Kroll; Alina Pisarevskaja; Fynn Brix; Bärbel Gruber; Gerald Rimbach; Frank Döring; Philip Rosenstiel; Andre Franke; Stefan Schreiber; Christian H C A Henning; Wolfgang Lieb; Ute Nöthlings; Karin Schwarz; Matthias Laudes Journal: Eur J Epidemiol Date: 2022-10-16 Impact factor: 12.434