Wenxiang Chu1,2, Xin Wang1,2, Yaokai Gan1,2, Yifu Zhuang1,2, Dingwei Shi2, Fengxiang Liu2, Yuehua Sun2, Jie Zhao1,2, Tingting Tang1, Kerong Dai1,2. 1. Shanghai Key Laboratory of Orthopaedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. 2. Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Abstract
Aim: To evaluate the clinical efficacy of mesenchymal stem cell/β-tricalcium phosphate composites (MSC/β-TCP) prepared with a screen-enrich-combine circulating system (SECCS) in patients with depressed tibial plateau fractures. Materials & methods: Bone defects in depressed tibial plateaus were filled with MSC/β-TCP (n = 16) or with β-TCP only (n = 23). Enrichment efficiency and effect of enrichment on cell viability were evaluated. Clinical results were assessed by imaging examination and Lysholm score. Results: SECCS effectively integrated MSCs with β-TCP. At 18 months postimplantation, new bone ratio was significantly higher in patients treated with MSC/β-TCP than in those treated with β-TCP only (p = 0.000). Patients with MSC/β-TCP implants had better functional recovery (p = 0.028). Conclusion: MSC/β-TCP prepared by SECCS were effective in the treatment of bone defects in patients with depressed tibial plateau fractures, promoted bone regeneration and improved joint function recovery.
Aim: To evaluate the clinical efficacy of mesenchymal stem cell/β-tricalcium phosphate composites (MSC/β-TCP) prepared with a screen-enrich-combine circulating system (SECCS) in patients with depressed tibial plateau fractures. Materials & methods: Bone defects in depressed tibial plateaus were filled with MSC/β-TCP (n = 16) or with β-TCP only (n = 23). Enrichment efficiency and effect of enrichment on cell viability were evaluated. Clinical results were assessed by imaging examination and Lysholm score. Results: SECCS effectively integrated MSCs with β-TCP. At 18 months postimplantation, new bone ratio was significantly higher in patients treated with MSC/β-TCP than in those treated with β-TCP only (p = 0.000). Patients with MSC/β-TCP implants had better functional recovery (p = 0.028). Conclusion: MSC/β-TCP prepared by SECCS were effective in the treatment of bone defects in patients with depressed tibial plateau fractures, promoted bone regeneration and improved joint function recovery.
Entities:
Keywords:
biomaterials; bone defect; bone regeneration; depressed tibial plateau fracture; enrichment technique; mesenchymal stem cell; β-tricalcium phosphate
Authors: Angelos Kaspiris; Argyris C Hadjimichael; Elias S Vasiliadis; Dionysios J Papachristou; Peter V Giannoudis; Elias C Panagiotopoulos Journal: J Clin Med Date: 2022-07-04 Impact factor: 4.964
Authors: Andrew Mott; Alex Mitchell; Catriona McDaid; Melissa Harden; Rachael Grupping; Alexandra Dean; Ailish Byrne; Laura Doherty; Hemant Sharma Journal: Bone Jt Open Date: 2020-10-06