BACKGROUND: Unhealthy pregnant women living in underdeveloped regions are usually treated by traditional healers, inadvertent of the potential toxic effects of plant-derivative substances. Thus, we investigated whether exposure to a hydroalcoholic extract of bark and seed of Libidibia ferrea during pregnancy results in fetotoxicity and maternal toxicity. The main constituents of both extracts were analyzed by High Performance Liquid Chromatography (HPLC). METHODS: Pregnant rats were divided into three groups: control (C), group exposed to extract of bark (Lfb-1.0 g/kg/day), and group exposed to extract of the seed (Lfs-1.0 g/kg/day). Biochemical parameters, reproductive capacity, morphological effects in the offspring were analyzed. RESULTS: HPLC fingerprint confirmed the presence of ellagic in both bark and seed extracts, and the absence of detectable concentrations of gallic and catechin. Fetuses exposed to L. ferrea extracts presented shorter mean lengths for head and body sections when compared to those in C and exhibited visceral and skeletal anomalies. Pregnant rats exposed to Lfs extracts show alterations in serum creatinine levels and yield amniotic fluid with abnormal biochemical composition. CONCLUSION: Bark or seed extracts of L. ferrea do not exhibit safety level compatible to be used in the gestational period.
BACKGROUND: Unhealthy pregnant women living in underdeveloped regions are usually treated by traditional healers, inadvertent of the potential toxic effects of plant-derivative substances. Thus, we investigated whether exposure to a hydroalcoholic extract of bark and seed of Libidibia ferrea during pregnancy results in fetotoxicity and maternal toxicity. The main constituents of both extracts were analyzed by High Performance Liquid Chromatography (HPLC). METHODS: Pregnant rats were divided into three groups: control (C), group exposed to extract of bark (Lfb-1.0 g/kg/day), and group exposed to extract of the seed (Lfs-1.0 g/kg/day). Biochemical parameters, reproductive capacity, morphological effects in the offspring were analyzed. RESULTS: HPLC fingerprint confirmed the presence of ellagic in both bark and seed extracts, and the absence of detectable concentrations of gallic and catechin. Fetuses exposed to L. ferrea extracts presented shorter mean lengths for head and body sections when compared to those in C and exhibited visceral and skeletal anomalies. Pregnant rats exposed to Lfs extracts show alterations in serum creatinine levels and yield amniotic fluid with abnormal biochemical composition. CONCLUSION: Bark or seed extracts of L. ferrea do not exhibit safety level compatible to be used in the gestational period.
Authors: Mário Rogério Lima Mota; José Ronildo Lins do Carmo Filho; Timna Varela Martins; Devany Quintela Soares; Mariana Pereira de Sousa; Paulo Goberlânio de Barros Silva; Ana Paula Negreiros Nunes Alves; Maria Gonçalves Pereira; Ana Maria Sampaio Assreuy Journal: Inflammopharmacology Date: 2022-08-03 Impact factor: 5.093
Authors: Diego Q Ferreira; Thamara O Ferraz; Raquel S Araújo; Rodrigo Alves Souza Cruz; Caio Pinho Fernandes; Gisele C Souza; Brenda L S Ortiz; Rosangela S F R Sarquis; Jemima C M M Miranda; Rafael Garrett; José C Tavares Carvalho; Anna Eliza M de Faria Mota Oliveira Journal: Pharmaceuticals (Basel) Date: 2019-11-30
Authors: Nair Silva Macêdo; Zildene de Sousa Silveira; Antonio Henrique Bezerra; José Galberto Martins da Costa; Henrique Douglas Melo Coutinho; Barbara Romano; Raffaele Capasso; Francisco Assis Bezerra da Cunha; Márcia Vanusa da Silva Journal: Molecules Date: 2020-08-23 Impact factor: 4.411