Genitourinary syndrome of menopause: effects on related factors, quality of life, and self-care power.

INTRODUCTION: This study aimed to determine the effects of genitourinary syndrome of menopause on related factors, quality of life, and self-care power.
MATERIAL AND METHODS: This case-control epidemiological study included 300 postmenopausal women aged 48-60 years who were divided into two groups: the case group (141) with genitourinary syndrome and the control group (159) without genitourinary syndrome. Data were evaluated by chi-square and t-tests in independent groups and logistic regression analysis.
RESULTS: The incidence of genitourinary syndrome of menopause was 0.61 times higher in women with a lower educational level than in those with a high educational level, 0.44 times higher in those with chronic disease than in those without, 2.54 times higher in those who continuously used medication than in those who did not, and 2.45 times higher in those with urinary incontinence than in those without. The mean Self-Care Power Scale score was significantly higher in the control group (101.52 ±21.50) than in the case group (83.96 ±25.64). The mean Menopause-Specific Quality of Life Scale score was significantly higher in the case group (65.52 ±33.47) than in the control group (37.06 ±25.81).
CONCLUSIONS: Low educational level, chronic disease, urinary incontinence, and continuous drug use are associated with genitourinary syndrome of menopause, which negatively affects the quality of life and self-care power in women.

Introduction

Genitourinary syndrome of menopause (GSM) is characterized by changes in the levels of sex hormones resulting in changes in the labia major/minor, clitoris, vestibule, vagina, urethra, and bladder. The terms vulvovaginal atrophy and atrophic vaginitis have been found to be insufficient to define menopausal symptoms associated with changes in the vulva, vagina, and lower urinary tract due to estrogen deficiency; thus, the term GSM has been developed for a more accurate and inclusive terminology. It provides accurate and comprehensive information about the general postmenopausal status [1].

The genitourinary syndrome that occurs during menopause causes dryness and dyspareunia (the most uncomfortable symptoms reported in clinical studies), staining or bleeding, burning, discomfort, and irritability in many women [1]. Increased vaginal basalization results in a persistent, malodorous discharge [2]. In their study of the effects of vulvovaginal atrophy in 1000 postmenopausal women, Simon et al. reported that 64% of women had painful sexual intercourse and loss of libido, and 58% of women avoided sexual intercourse [3]. Pastore et al. reported that the most common genitourinary symptoms were vaginal dryness (27%), vaginal irritation or pruritus (18.6%), vaginal discharge (11.1%), and dizziness (5.2%) in a study of women’s health [4]. Genitourinary syndrome causes negative vaginal problems as well as frequent emotional distress, leading to adverse effects on the quality of life of women with menopause [5-8].

Genitourinary syndrome of menopause affects approximately 50% of middle-aged and elderly women [1, 2, 9-11]. With the development of health services, the increase in diagnostic and treatment possibilities has prolonged human life span. According to 2011 data of the Turkey Statistical Institute, the innate life expectancy of women in Turkey is 77.1 years, whereas, according to the 2013 TUIK data, it increased to 79.4 years [12-14]. In this case, a woman will spend one-third of her life in the menopausal period on average and even more in the future. The World Health Organization projects that, by 2030, an estimated 1.2 billion women will be over 50 years of age, i.e., menopausal. Understanding menopause and preventing its effects and outcome are the most important tasks to increase the quality of life of women over 50 years of age. Although it is difficult to deal with social and cultural taboos, many believe that health workers should urgently improve the situation. First, it is necessary to investigate the results of GSM to determine the dimensions of the problem, quality of life, and its effects on self-care power [15].

Aim of the study

The present study was conducted to determine the effects of GSM on related factors, quality of life, and self-care power.

Material and methods

Study design and participants

This case-control epidemiological study was conducted between September 2016 and May 2017 and consisted of women in the postmenopausal period aged 48-60 years who presented to family health centers. The sample size of the study was calculated as 140 women for the case group and 140 postmenopausal women for the control group according to the G* Power 3.1.5 program [16]. The case group (141) and the control group (159) included postmenopausal women who met the study criteria in the specified date range and agreed to participate in the study. The case group consisted of women with GSM, whereas the control group consisted of women without GSM.

The Menopausal Symptom Assessment Scale was used to evaluate the case and control groups. The ratings of the urogenital complaints subscale were classified as “mild”, “moderate”, “severe”, or “very severe”, and women who provided such ratings were defined as “those living with GSM”, while those who did not were defined as “those without genitourinary syndrome”. The urogenital complaints subscale of the Menopausal Symptom Assessment Scale is categorized into three aspects: 1) sexual problems (change in sexual desire, sexual relations, and satisfaction), 2) urinary problems (difficulties during urination, frequent urination, incontinence), and 3) vaginal problems (dryness and burning sensation in the vagina and strain on sexual intercourse). The case group of the study included those living with GSM, willing to participate in the study. The control group of the study included those without genitourinary syndrome, similar to the case group in terms of sociodemographic data and willing to participate in the study.

Measures

The Participant Information Form, Menopausal Symptoms Assessing Scale (MSAS), Menopause-Specific Quality of Life Scale (MSQLS), and Self-Care Power Scale (SCPS) were used for data collection. Data were gathered by face-to-face interviews with women in family health centers.

Participant information form

This form was prepared by the researchers in accordance with the literature. It contains the following information of women: socio-demographic characteristics (age, body mass index, education, employment status, income status, marital status, satisfaction with marital status, having chronic illness, continuous drug use, and smoking status) and gyneco-obstetric features (number of pregnancies, duration of menopause, gynecologic state of operation, presence of urinary incontinence, causes of urinary incontinence, treatment received, and perception of menopause). Seventeen questions were considered to be related to menopause. Rare incontinence is defined as “incontinence occurring one or more times per month”, regular incontinence is defined as “incontinence occurring two or more times per month”, and severe incontinence is defined as “incontinence with continuous use of a pad, regardless of frequency” [17].

Menopausal Symptoms Assessing Scale

Menopausal Symptoms Assessing Scale (MSAS) was developed in Germany by Schneider et al. [18] and was adapted to English in 1996. In Turkey, the translation and adaptation of this scale to Turkish was done by Gürkan [19]. The scale consists of somatic, psychological, and urogenital symptom subdimensions. The Likert-type scale consists of 11 items, with the following options: “0 = none”, “1 = light”, “2 = medium”, “3 = severe”, and “4 = very severe”. The total score of the scale is calculated based on the scores given for each item. The Cronbach’s α reliability coefficient was 0.84. In contrast, the increase in the total score on the scale indicates an increase in the severity of the complaints experienced, indicating that the quality of life is adversely affected [19].

Menopause-Specific Quality of Life Scale

Menopause-Specific Quality of Life Scale (MSQLS) was developed by Hilditch et al. [20] and adapted to Turkish by Kharbouch and Şahin [21], and studies of its validity and reliability have been conducted. The scale consists of 29 Likert-type items classified into vasomotor, psychosocial, physical, and sexual topics. Women were asked about their complaints in the last month. If the answer was “Yes”, the severity of the complaint was scored between 0 and 6, wherein 0 indicated “did not bother me at all” and 6 indicated “overwhelming” based on the degree of the individual’s discomfort. In the analysis, each question item was scored between 1 and 8 points, with 1 point indicating “no problem” and 2 points indicating “presence of problems but not disturbing”. Moreover, 3-8 points described the severity of the problem and its increasing relevance. Because the number of questions per topic varied, the average of the scores was evaluated as the overall score of each item. Each question has a total score between 1 and 8; a low score indicates a high quality of life [20].

Self-Care Power Scale

Self-Care Power Scale (SCPS) was developed by Kearney and Fleisher [22] and was adapted by Nahcivan [23], who conducted validity and reliability studies. The scale consists of 35 Likert-type items, with the following options: “do not define me at all”, “agree”, “no idea”, “define me a little”, and “define me greatly”. Each expression on the scale is evaluated between 0 and 4 points. Eight self-rated health claims are considered negative. For this reason, scoring is reversed for negative expressions [23].

Statistical analysis

Data coding and evaluation were performed using the SPSS 20.0 package program. Statistical analysis was conducted using descriptive statistics and the chi-square test for comparing percentile data between groups, the independent t-test for comparing the mean in normally distributed parametric data, and logistic regression analysis for determining the factors associated with GSM.

Limitations of the study

The presence of genitourinary syndrome was not determined by physical examination findings.

Results

When the socio demographic characteristics of the case group were examined, 48.2% of women were aged 57-60 years, 58.2% were overweight, 71.6% were primary school graduates, 90.8% were unemployed, 66% perceived income equal to their expenses, 73.8% were married, 35.5% were satisfied with marital life, 62.4% had a chronic disease, 66% used drugs continuously, and 80.9% did not use cigarettes. In the control group, 48.4% of women were aged 57-60 years, 48.4% were overweight, 60.4% were primary school graduates, 76.1% were unemployed, 62.3% perceived income equal to their expenses, 73% were married, 40.3% were satisfied with marital life, 58.5% had a chronic illness, 68.6% used drugs continuously, and 73% did not use cigarettes. On comparing the case and control groups in terms of sociodemographic characteristics, there was a statistically significant relationship between education (p ≤ 0.001), employment status (p = 0.001), income status perception (p = 0.002), and marital satisfaction (p = 0.003) (Table 1). The proportion of women who were unemployed, had low educational status and low income, and were dissatisfied with their marital life was lower in the GSM case group than in the control group.

Table 1

Comparison of case and control groups in terms of sociodemographic characteristics

Sociodemographic characteristics	Case group n (%)	Control group n (%)	Significance value
Age group			χ2 = 0.381p = 0.827
48-51	32 (22.7)	40 (25.2)
52-56	41 (29.1)	42 (26.4)
57-60	68 (48.2)	77 (48.4)
Body mass index (kg/m2)			χ2 = 4.985p = 0.083
18.5-24.9	9 (6.3)	21 (13.2)
25-29.9	50 (35.5)	61 (38.4)
≥ 30	82 (58.2)	77 (48.4)
Level of education			χ2 = 24.468p = 0.000
I have never been educated	26 (18.5)	13 (8.2)
Primary school	101 (71.6)	96 (60.4)
High school	14 (9.9)	36 (22.6)
University	–	14 (8.8)
Working status			χ2 = 10.396p = 0.001
Working	13 (9.2)	38 (23.9)
Not working	128 (90.8)	121 (76.1)
Income perception			χ2 = 12.722p = 0.002
Income less than their expenses	22 (15.6)	9 (5.6)
Income equal to their expenses	93 (66.0)	99 (62.3)
Income more than their expenses	26 (18.4)	51 (32.1)
Marital status			χ2 = 0.025p = 0.875
Married	104 (73.8)	116 (73.0)
Not married	37 (26.2)	43 (27.0)
Satisfaction with marital life			χ2 = 13.772p = 0.003
I am not satisfied	16 (11.4)	–
Satisfied	50 (35.5)	64 (40.3)
I am very pleased	38 (27.09)	52 (32.7)
I am not married	37 (26.2)	43 (27.0)
Having chronic illness			χ2 = 0.480p = 0.488
Yes	88 (62.4)	93 (58.5)
No	53 (37.6)	66 (41.5)
Continuous drug use			χ2 = 0.229p = 0.632
Yes	93 (66.0)	109 (68.6)
No	48 (34.0)	50 (31.4)
Smoking			χ2 = 2.181p = 0.140
Yes	27 (19.1)	43 (27.0)
No	114 (80.9)	116 (73.0)

When gyneco-obstetric features of women in the case group were examined, 83.7% had three or more pregnancies, 63.8% had been in the menopausal period for 4 or more years, 63.1% did not undergo gynecologic surgery, 31.9% had no urinary incontinence, and 21.3% reported urinary incontinence when they felt sudden urination, 87.2% received no menopause treatment, and 61% had a negative perception of the menopausal period. In the control group, 79.9% of women had three or more pregnancies; 73.6% had been in menopausal period for 4 or more years; 65.4% did not undergo gynecologic surgery; 68.6% had no urinary incontinence; 13.2% reported urinary incontinence during physical activity, laughing, or sneezing; 92.5% received no menopause treatment; and 56% had a positive perception of the menopausal period. There was a statistically significant relationship between the case and control groups in terms of gyneco-obstetric characteristics, such as urinary incontinence (p = 0.000), and menopausal perception (p = 0.003) (Table 2). The proportion of women who reported severe urinary incontinence when there was a sudden urge to urinate and who perceived menopause as negative was higher in the case group than in the control group.

Table 2

Comparison of gyneco-obstetric characteristics of case and control groups

Gyneco-obstetric characteristics	Case group n (%)	Control group n (%)	Significance value
Number of pregnancies			χ2 = 3.422p = 0.331
1	11 (7.8)	10 (6.3)
2	12 (8.5)	22 (13.8)
3 and over	118 (83.7)	127 (79.9)
Menopause duration (years)			χ2 = 3.391p = 0.335
1	21 (14.9)	17 (10.7)
2	13 (9.2)	10 (6.3)
3	17 (12.1)	15 (9.4)
4 and over	90 (63.8)	117 (73.6)
Gynecologic surgery status			χ2 = 0.171p = 0.680
Yes	52 (36.9)	55 (34.6)
No	89 (63.1)	104 (65.4)
Urinary incontinence			χ2 = 52.436p = 0.000
Never	45 (31.9)	109 (68.6)
Rare incontinence	43 (30.5)	37 (23.3)
Regular incontinence	31 (22.0)	–
Severe incontinence	22 (15.6)	13 (8.1)
Cause of urinary incontinence			χ2 = 52.418p = 0.000
Physical activity, laughing, sneezing	25 (17.7)	21 (13.2)
When there is a sudden urination feeling	30 (21.3)	13 (8.1)
In both cases	24 (17.0)	–
In situations other than these	17 (12.1)	16 (10.1)
I am never incontinent	45 (31.9)	109 (68.6)
Menopause treatment			χ2 = 1.719p = 0.190
No	123 (87.2)	147 (92.5)
Yes (hormone replacement therapy)	18 (12.8)	12 (7.5)
Perception of the menopausal period			χ2 = 8.620p = 0.003
Positive	55 (39.0)	89 (56.0)
Negative	86 (61.0)	70 (44.0)

A comparison of the mean scores of the scales between the case and control groups is presented in Table 3. The mean SCPS score was significantly higher in the control group (101.52 ±21.50) than in the case group (83.96 ±25.64). However, the mean MSQLS score was significantly higher in the case group (65.52 ±33.47) than in the control group (37.06 ±25.81). The mean scores of the vasomotor (p = 0.000), psychosocial (p = 0.000), physical (p = 0.000), and sexual (p = 0.000) areas were significantly different between the case group and the control group (Table 3).

Table 3

Comparison of SCPS and MSQLS scores in case and control groups

Scales	Case group (X ±SS)	Control group (X ±SS)	t	p
Self Care Power	83.96 ±25.64	101.52 ±21.50	6.449	0.000
Menopause-Specific Living Quality	65.52 ±33.47	37.06 ±25.81	–8.294	0.000
Vasomotor Field	8.01 ±4.65	5.54 ±4.62	–4.613	0.000
Psychosocial Field	15.09 ±10.49	6.85 ±7.56	–7.864	0.000
Physical Field	38.84 ±21.33	23.11 ±16.40	–7.200	0.000
Sexual Field	3.58 ±4.64	1.56 ±3.68	–4.200	0.000

The results of logistic regression analysis to investigate the variables affecting the genitourinary syndrome revealed that the incidence of GSM in less educated women was 0.61 times (p = 0.004) higher than that in highly educated women, in women with chronic illness it was 0.44 times (p = 0.042) higher than that in those without chronic illness, and in women with urinary incontinence it was 2.45 times higher (p = 0.000) than that in those without urinary incontinence (Table 4).

Table 4

Factors associated with genitourinary syndrome (logistic regression results)

Variable	β	SE	Wald	p	Exp(B)
Age	–0.117	0.219	0.286	0.593	0.890
Working status	–0.907	0.479	3.586	0.058	0.404
Level of education	–0.492	0.173	8.143	0.004	0.611
Body mass index	0.076	0.225	0.113	0.737	1.078
Income perception	0.002	0.271	0.000	0.993	1.002
Marital status	–0.634	0.603	1.106	0.293	0.530
Satisfaction with marital life	–0.502	0.283	3.157	0.076	0.605
Having chronic illness	–0.821	0.405	4.119	0.042	0.440
Continuous drug use	0.936	0.434	4.654	0.031	2.549
Smoking	–0.135	0.357	0.144	0.704	0.873
Number of pregnancies	–0.310	0.223	1.933	0.164	0.733
Menopause duration (years)	–0.204	0.153	1.784	0.182	0.815
Gynecologic surgery status	0.594	0.311	3.638	0.056	1.811
Urinary incontinence	0.899	0.179	25.214	0.000	2.456
Menopause treatment	0.722	0.481	2.251	0.134	2.059
Perception of the menopausal period	0.075	0.312	0.057	0.811	1.077
Constant	3.209	2.691	1.421	0.233	24.747

Model χ2 = 85.051, p = 0.000, R2 = 0.330

Discussion

Genitourinary symptoms associated with menopause and aging are usually permanent and persistent, as opposed to menopausal symptoms that disappear from time to time, such as hot flashes [1, 2, 24]. Previous studies have reported that GSM affects approximately 50% of middle-aged and elderly women [1, 2, 9-11]. Although GSM affects about half of women in the postmenopausal period, most women have no knowledge of the causes and effects of this condition.

In the present study, the incidence of GSM was higher in unemployed women with a low educational level and income. Oğurlu et al. found in their investigation that menopause-specific urogenital problems occurred more frequently in unemployed women [25]. In the study of Çelik and Pasinlioğlu, educational level, employment status, and income status perception did not affect menopausal complaints, which was contrary to our findings [26]. Although similar in terms of sociodemographic characteristics, we believe that the results are different because the studies were conducted in different regions. Studies show that large differences both between and within cultures are influential in the perception of menopause, in terms of the menopausal behaviors and complaints in this period [27, 28]. Therefore, to ensure the healthy well-being of postmenopausal women, the implementation of culturally appropriate mitigation and management strategies is necessary [28].

In the present study, the incidence of GSM was higher in women who were dissatisfied with their marital life. Studies have shown that women who are satisfied with their marital life have fewer menopausal complaints and a higher quality of life [26, 29-31]. The findings of the present study are comparable to those of other studies.

In the present study, the incidence of GSM was high in women who perceived menopause as negative. In Turkish society, menopause is negatively perceived by women [27, 32-34]. Yanikkerem et al. indicated that the severity of menopausal complaints is related to the attitude toward menopause [35]. Furthermore, Zivdir and Sohbet stated that the quality of life is lower in women who perceived menopause as a negative situation and feel guilty due to menopausal complaints [36]. Studies have shown that women with positive menopausal attitudes have a greater ability to cope with GSM [30, 37, 38]. The literature findings support our study.

In the present study, the mean SCPS score was 83.96 ±25.64 in the case group and 101.52 ±21.50 in the control group. Women living with GSM were found to have a lower self-care power. Women’s lower educational level and income perception may be related to the low number of working women. In their study of postmenopausal women aged 45-55 years, Özgür et al. found a relationship among low educational level, income perception, unemployment status, and low self-care power [12]. These factors can lead to women having a lower self-care power. The continuity and progression of symptoms can also negatively affect women’s self-care.

Women not living with GSM had a higher menopausal quality of life. Similar studies have shown that menopausal symptoms have negative effects on quality of life [1, 2, 9-11, 31, 39]. Nappi et al. stated that the quality of life of 52% of women in the postmenopausal period was adversely affected in terms of their sexual life, self-esteem, marriage compatibility, and social life [7]. Tohma et al. reported that vulvovaginal atrophy is a common disorder characterized by the hypoestrogenic state of the urogenital tissue and that irritation, dryness, painful sexual intercourse, and urinary symptoms seriously affect the quality of life of women [40]. Many studies have found that irritation, burning, dryness, and dyspareunia affect the sexual life of women, consequently decreasing quality of life [41, 42]. It is known that the symptoms of menopause affect the quality of life, and that each woman should be evaluated according to their own health status [43].

Women with a low educational level are 0.61 times more likely to have GSM than those with high levels of education. In the literature, it is stated that women with a low educational level had more menopausal complaints [21, 44, 45]. This may be attributed to the fact that women with a low educational level cannot develop effective coping strategies and are unable to receive treatment.

Genitourinary syndrome of menopause is 0.44 times more likely to occur in women with chronic disease and 2.54 times more likely in continuous drug users. Kharbound and Şahin indicate that women with chronic illness have severe menopausal complaints [21]. This result is thought to be related to the increased risk for diseases, such as osteoporosis and cardiovascular diseases, owing to a decrease in the estrogen level and menopause.

In the present study, the incidence of GSM was 2.45 times higher in women who had urinary incontinence in a serious and sudden situation. In a study conducted with 9000 postmenopausal women in the United States, vaginal atrophy was shown to significantly correlate with other urogenital symptoms [46]. Demir ve Kızılkaya Beji stated that women who entered menopause more frequently experienced urinary incontinence, and their quality of life was affected more negatively [47]. Yilmaz et al. determined that menopause is an important risk factor for incontinence [48]. This result shows that the decrease in the estrogen level with menopause also affects the lower urinary tract, thus providing the basis for the formation of urinary incontinence.

Conclusion and recommendations

Low educational level, chronic disease, urinary incontinence, and continuous drug use have been found to be significantly associated with the occurrence of GSM. Moreover, GSM negatively affects the quality of life and self-care power of women. In line with these results:

in the presentation of health services, women with menopausal symptoms should be evaluated for genitourinary symptoms and directed to appropriate diagnosis and treatment services;

development and implementation of supportive programs to increase self-care power and quality of life of women and qualitative research on the subject are recommended.

Ethical approval

Prior to the investigation, approval from the ethics committee (dated November 18, 2016, approval no. 2016/003) and a hospital permit were obtained. Before starting collection of research data, women were informed about the study, and their questions were answered. Informed consent was obtained verbally. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Disclosure

The authors report no conflict of interest.