Jean-Paul Claudel1, Nicole Auffret2, Marie-Thérèse Leccia3, Florence Poli2, Stéphane Corvec4, Brigitte Dréno5. 1. Private Practice, Tours, France. 2. Private Practice, Paris, France. 3. Department of Dermatology, Allergology and Photobiology, CHU A. Michallon, Grenoble, France. 4. CHU Nantes, Service de Bactériologie-Hygiène Hospitalière, CRCINA, INSERM, U1232, Université de Nantes, Nantes, France. 5. UF dermato-cancérologie, CHU Nantes-Hôtel-Dieu, Inserm U1232, CIC Biothérapie Inserm 05031, Nantes, France, brigitte.dreno@atlanmed.fr.
Abstract
BACKGROUND: Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such as Staphylococcus epidermidis, in the physiopathology of this skin disease. SUMMARY: This review provides an overview of current knowledge of the potential role of S. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium between C. acnes and S. epidermidis,according to dedicated interactions. Current treatments act on C. acnesonly. Other treatment options may be considered, such as probiotics derived from S. epidermidis to restore the naturally balanced microbiota or through targeting the regulation of the host's AMP mediators. Key Messages: Research seems to confirm the beneficial role of S. epidermidis in acne by limiting C. acnes over-colonisation and inflammation.
BACKGROUND:Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such as Staphylococcus epidermidis, in the physiopathology of this skin disease. SUMMARY: This review provides an overview of current knowledge of the potential role of S. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium between C. acnes and S. epidermidis,according to dedicated interactions. Current treatments act on C. acnesonly. Other treatment options may be considered, such as probiotics derived from S. epidermidis to restore the naturally balanced microbiota or through targeting the regulation of the host's AMP mediators. Key Messages: Research seems to confirm the beneficial role of S. epidermidis in acne by limiting C. acnes over-colonisation and inflammation.
Authors: Kun Liang; Cheryl Leong; Jia Min Loh; Nathania Chan; Larissa Lim; Yuen In Lam; Thomas L Dawson; Hong Liang Tey Journal: Proc Natl Acad Sci U S A Date: 2022-07-22 Impact factor: 12.779