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Literature DB >> 3111280

CO2 challenge of patients with panic disorder.

M R Fyer, J Uy, J Martinez, R Goetz, D F Klein, A Fyer, M R Liebowitz, J Gorman.

Abstract

In an open trial, five of eight panic disorder patients and none of five control subjects panicked after inhalation of two breaths of 35% CO2 and 65% O2; none panicked after placebo. Using 35% CO2 to induce panic is safe, simple, and well tolerated and may provide a valuable laboratory model of panic.

Entities: Chemical Disease Species

Mesh：

Substances：
Carbon Dioxide
Oxygen

Year: 1987 PMID： 3111280 DOI： 10.1176/ajp.144.8.1080

Source DB: PubMed Journal: Am J Psychiatry ISSN： 0002-953X Impact factor: 18.112

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Cited

9 in total

1. Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype × testosterone interaction.

Authors: Robert A Josephs; Michael J Telch; J Gregory Hixon; Jacqueline J Evans; Hanjoo Lee; Valerie S Knopik; John E McGeary; Ahmad R Hariri; Christopher G Beevers
Journal: Psychoneuroendocrinology Date: 2011-10-05 Impact factor: 4.905

Review 2. Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder.

Authors: Jason J Paris; Christine Franco; Ruthlyn Sodano; Brian Freidenberg; Elana Gordis; Drew A Anderson; John P Forsyth; Edelgard Wulfert; Cheryl A Frye
Journal: Horm Behav Date: 2009-06-16 Impact factor: 3.587

CO2 challenge of patients with panic disorder.

1. Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype × testosterone interaction.

Review 2. Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder.

3. Exploring human freeze responses to a threat stressor.

4. Fear responding to 35% CO(2) challenge as a vulnerability marker for later social anxiety symptoms.

5. Yohimbine premedication and 35% CO2 vulnerability in healthy volunteers.

6. Anxiety sensitivity profile: predictive and incremental validity.

7. Efficacy of chronic antidepressant treatments in a new model of extreme anxiety in rats.

8. CO2 exposure as translational cross-species experimental model for panic.

9. Brain Circulation during Panic Attack: A Transcranial Doppler Study with Clomipramine Challenge.