| Literature DB >> 3111175 |
M Elam, T H Svensson, P Thorén.
Abstract
Brain monoamine metabolism in rats was studied during spontaneous, long-term running in a microprocessor-controlled wheel cage. Immediately after heavy spontaneous exercise, DOPA accumulation was decreased in dopamine-rich brain regions such as the limbic forebrain and corpus striatum, indicating a decreased rate of synthesis of dopamine in brain. In contrast, DOPA accumulation was increased in the noradrenaline-predominated region of the brain stem, indicating an increased synthesis of noradrenaline in this region. Alterations in brain monoamine metabolism were normalized in exercising animals analysed 24 h after the last running period. Changes in brain monoamine metabolism may be involved in the mechanisms underlying the clinically observed psychological effects of physical exercise.Entities:
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Year: 1987 PMID： 3111175 DOI： 10.1111/j.1748-1716.1987.tb08142.x
Source DB: PubMed Journal: Acta Physiol Scand ISSN： 0001-6772