| Literature DB >> 31110403 |
Stefano Gumina1, Martina Leopizzi2, Michele Carnovale3, Natale Porta2, Giuseppe Giannicola3, Ciro Villani3, Vittorio Candela1.
Abstract
The development of a periostin-rich microenvironment in areas associated with insult, orchestrating pathways of repair and rebuilding, is documented. Literature lacks information regarding the presence of periostin in the context of rotator cuff tear (RCT). 55 consecutive patients with RCT were enrolled. Immunohistochemical periostin detection was performed on tissue samples excised from tear margins. Our study documented the presence of periostin in the margins of RCT. It is plausible that, when a tear occurs, multiple stimuli, both mechanical and inflammatory, lead to the development of a periostin-rich microenvironment as an attempt to tendon healing.Entities:
Keywords: Periostin properties; Periostin synthesis; Rotator cuff tear healing; Shoulder tendon disease; Tendon healing
Year: 2019 PMID： 31110403 PMCID： PMC6512582 DOI： 10.1016/j.jor.2019.04.018
Source DB: PubMed Journal: J Orthop ISSN： 0972-978X