| Literature DB >> 31109795 |
April H Nguyen1, William R Miller2, Cesar A Arias3.
Abstract
Vancomycin-resistant Enterococcus faecium (VRE) is a major cause of nosocomial infections. A new study by McKenney et al. (Cell Host Microbe 2019;25:695-705.e5) reports that VRE undergo a morphotype switch in response to lithocholic acid (LCA) to facilitate gastrointestinal (GI) tract colonization. This metabolic cue is a potential target to decrease VRE colonization and subsequent transmission of antibiotic resistance.Entities:
Keywords: Enterococcus; GI colonization; VRE; antibiotic resistance; daptomycin
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Year: 2019 PMID： 31109795 DOI： 10.1016/j.molmed.2019.04.011
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951