Literature DB >> 31109647

microRNA-16-5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1.

Jingjing Xu1, Liping Zhang2, Guobin Shu3, Bin Wang4.   

Abstract

Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes. miR-16-5p has been reported to be involved in cell proliferation, apoptosis, differentiation and angiogenesis. However little is known about miR-16-5p functional role in 3T3-L1 adipocyte differentiation. In this study, we found that miRNA-16-5p was significantly upregulated during 3T3-L1 preadipocytes differentiation towards mature adipocytes. Over-expression of miRNA-16-5p promoted mature adipocytes specific genes expression and fat droplet accumulation in vitro and in vivo. Meanwhile we have identified EPT1 as the target gene of miRNA-16-5p. Taken together, our data provided evidence to support that miRNA-16-5p promotes adipocyte differentiation by suppressing EPT1.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  3T3-L1 adipocyte; Differentiation; EPT1; microRNA-16–5p

Year:  2019        PMID： 31109647     DOI： 10.1016/j.bbrc.2019.04.179

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


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