Xi Zhang1, Siwei Xie1, Jingwu Yang1, Fenghua Weng2, Jianfeng Xu1, Qiu Huang2, Qiyu Peng3. 1. School of Mechanical Science and Engineering, Huazhong University of Science and Technology, 430074, Wuhan, China. 2. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, China. 3. Department of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, 94720, Berkeley, CA, USA.
Abstract
PURPOSE: Depth of interaction (DOI) decoding capability is of great importance for positron emission tomography (PET) requiring high resolution. In this study, we presented a novel low-cost DOI detector design with four crystals coupling to one SiPM, based on the method of rectangular light-sharing window (RLSW). A prototype detector was constructed, calibrated, and assessed using the methods of homogeneous radiation and flood map analysis. METHODS: The DOI detector was constructed with a 4 × 4 array of lutetium-yttrium oxyorthosilicate (LYSO) crystals (2.95 mm × 2.95 mm × 20 mm3 ), barium sulfate (BaSO4 ) reflectors, and optical glues. A RLSW 7 mm in height was deployed in the BaSO4 reflectors. A non-DOI detector with identical dimensions and without RLSW was also constructed for comparison. The light-output surface of the detector was air-coupled with a 4 × 4 array of SiPMs (3 mm × 3 mm2 ). The signals generated from the 16 SiPMs were read out by a custom-designed electronic system, and the signals from four adjacent 3 mm SiPMs were summed into one signal to emulate a 2 × 2 array of 6 mm SiPMs. The RLSW caused the DOI-related position shifts of the crystal spots in the flood map. A homogeneous radiation method was used to establish the transfer functions to convert the spot shifts measured from the flood map into DOI measurements. The accuracy of the DOI measurements was assessed with data acquired using the conventional collimated radiation method. RESULTS: All 16 crystals are distinctly separated from each other in the flood map. Twelve crystals, including four central crystals and eight edge crystals, have the DOI capability. The full width half maximum (FWHM) of the DOI measurements of the central crystals and the edge crystals are 3.06 ± 0.08 and 3.79 ± 0.15 mm, respectively, for the configuration with four crystals coupling to one SiPM. By contrast, the FWHMs (3.98 ± 0.16 and 5.12 ± 0.38 mm, respectively) are slightly worse for the configuration with one crystal coupling to one SiPM. The average and standard deviation (STD) of the FWHM energy resolutions of the DOI detector and non-DOI detector were 10.2% ± 0.7% and 10.7% ± 1.7%, respectively. Their FWHM coincidence timing resolutions were 197.0 ± 9.6 and 206.4 ± 13.3 ps, respectively. The RLSW had no significant impact on the energy resolutions and timing resolutions of the DOI detector. CONCLUSIONS: The novel four-crystals-to-one-SiPM coupling technology is a cost-efficient approach to construct high-performance detector modules with DOI capability. The methods of homogeneous radiation and flood map analysis are easy to perform and of good performance. Those methods can be adapted in the clinic PET scanners to enable the capability of DOI measurements.
PURPOSE: Depth of interaction (DOI) decoding capability is of great importance for positron emission tomography (PET) requiring high resolution. In this study, we presented a novel low-cost DOI detector design with four crystals coupling to one SiPM, based on the method of rectangular light-sharing window (RLSW). A prototype detector was constructed, calibrated, and assessed using the methods of homogeneous radiation and flood map analysis. METHODS: The DOI detector was constructed with a 4 × 4 array of lutetium-yttrium oxyorthosilicate (LYSO) crystals (2.95 mm × 2.95 mm × 20 mm3 ), barium sulfate (BaSO4 ) reflectors, and optical glues. A RLSW 7 mm in height was deployed in the BaSO4 reflectors. A non-DOI detector with identical dimensions and without RLSW was also constructed for comparison. The light-output surface of the detector was air-coupled with a 4 × 4 array of SiPMs (3 mm × 3 mm2 ). The signals generated from the 16 SiPMs were read out by a custom-designed electronic system, and the signals from four adjacent 3 mm SiPMs were summed into one signal to emulate a 2 × 2 array of 6 mm SiPMs. The RLSW caused the DOI-related position shifts of the crystal spots in the flood map. A homogeneous radiation method was used to establish the transfer functions to convert the spot shifts measured from the flood map into DOI measurements. The accuracy of the DOI measurements was assessed with data acquired using the conventional collimated radiation method. RESULTS: All 16 crystals are distinctly separated from each other in the flood map. Twelve crystals, including four central crystals and eight edge crystals, have the DOI capability. The full width half maximum (FWHM) of the DOI measurements of the central crystals and the edge crystals are 3.06 ± 0.08 and 3.79 ± 0.15 mm, respectively, for the configuration with four crystals coupling to one SiPM. By contrast, the FWHMs (3.98 ± 0.16 and 5.12 ± 0.38 mm, respectively) are slightly worse for the configuration with one crystal coupling to one SiPM. The average and standard deviation (STD) of the FWHM energy resolutions of the DOI detector and non-DOI detector were 10.2% ± 0.7% and 10.7% ± 1.7%, respectively. Their FWHM coincidence timing resolutions were 197.0 ± 9.6 and 206.4 ± 13.3 ps, respectively. The RLSW had no significant impact on the energy resolutions and timing resolutions of the DOI detector. CONCLUSIONS: The novel four-crystals-to-one-SiPM coupling technology is a cost-efficient approach to construct high-performance detector modules with DOI capability. The methods of homogeneous radiation and flood map analysis are easy to perform and of good performance. Those methods can be adapted in the clinic PET scanners to enable the capability of DOI measurements.