Literature DB >> 31106806

Ultrasensitive detection of long non-coding RNAs based on duplex-specific nuclease-actuated cyclic enzymatic repairing-mediated signal amplification.

Yan Zhang1, Xin-Yan Wang, Xianwei Su, Chun-Yang Zhang.   

Abstract

We develop a new fluorescent method for sensitive detection of long noncoding RNAs (lncRNAs) on the basis of duplex-specific nuclease-actuated cyclic enzymatic repairing-mediated signal amplification. This method exhibits high sensitivity with a detection limit of 0.081 fM, and it can accurately detect the endogenous lncRNA HOTAIR in cancer cells, providing a new approach to study the physiological function of lncRNAs in human diseases.

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Year:  2019        PMID： 31106806     DOI： 10.1039/c9cc02939g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  An Interfacial Affinity Interaction-Based Method for Detecting HOTAIR lncRNA in Cancer Plasma Samples.

Authors:  Kimberley Clack; Narshone Soda; Surasak Kasetsirikul; Richard Kline; Carlos Salomon; Muhammad J A Shiddiky
Journal:  Biosensors (Basel)       Date:  2022-04-28

Review 2.  Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection.

Authors:  Hongke Qu; Chunmei Fan; Mingjian Chen; Xiangyan Zhang; Qijia Yan; Yumin Wang; Shanshan Zhang; Zhaojian Gong; Lei Shi; Xiayu Li; Qianjin Liao; Bo Xiang; Ming Zhou; Can Guo; Guiyuan Li; Zhaoyang Zeng; Xu Wu; Wei Xiong
Journal:  J Nanobiotechnology       Date:  2021-12-04       Impact factor: 10.435

3.  A simple and rapid colorimetric detection of serum lncRNA biomarkers for diagnosis of pancreatic cancer.

Authors:  Ut Kei Lou; Chi Hin Wong; Yangchao Chen
Journal:  RSC Adv       Date:  2020-02-25       Impact factor: 4.036
  3 in total

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