BACKGROUND: In 2007 the International Psoriasis Council considered palmoplantar pustulosis (PPP) a condition separate from psoriasis, and several authors maintain that PPP is a reactive process to metal contact allergies independent from psoriasis. OBJECTIVES: To evaluate the frequency of allergies and psoriasis in patients with PPP and to determine the role of allergens in PPP. METHODS: A systematic search of the English databases (PubMed and Web of Science) from January 1964 to August 2018 to identify all patients affected by PPP and allergies and/or psoriasis. RESULTS: In total, 16 publications describing a total of 519 patients with PPP were evaluated and 122 cases of concomitant PPP and metal allergy were found. The frequency of allergies among patients with PPP was 22.7%; between the identified allergens, 84.3% of cases correspond to metal allergies. In 65.1% of metal allergies, an improvement in PPP was seen after withdrawal of contact. The concomitant presence of psoriasis was recorded in 18% of the cases. CONCLUSION: There is some evidence to support the association of PPP with metal allergies but also with psoriasis, suggesting the role of metal allergens as a trigger factor in patients with PPP.
BACKGROUND: In 2007 the International Psoriasis Council considered palmoplantar pustulosis (PPP) a condition separate from psoriasis, and several authors maintain that PPP is a reactive process to metal contact allergies independent from psoriasis. OBJECTIVES: To evaluate the frequency of allergies and psoriasis in patients with PPP and to determine the role of allergens in PPP. METHODS: A systematic search of the English databases (PubMed and Web of Science) from January 1964 to August 2018 to identify all patients affected by PPP and allergies and/or psoriasis. RESULTS: In total, 16 publications describing a total of 519 patients with PPP were evaluated and 122 cases of concomitant PPP and metal allergy were found. The frequency of allergies among patients with PPP was 22.7%; between the identified allergens, 84.3% of cases correspond to metal allergies. In 65.1% of metal allergies, an improvement in PPP was seen after withdrawal of contact. The concomitant presence of psoriasis was recorded in 18% of the cases. CONCLUSION: There is some evidence to support the association of PPP with metal allergies but also with psoriasis, suggesting the role of metal allergens as a trigger factor in patients with PPP.
Authors: C E M Griffiths; E Christophers; J N W N Barker; R J G Chalmers; S Chimenti; G G Krueger; C Leonardi; A Menter; J-P Ortonne; L Fry Journal: Br J Dermatol Date: 2007-02 Impact factor: 9.302
Authors: K Nakamura; S Imakado; M Takizawa; M Adachi; M Sugaya; M Wakugawa; A Asahina; K Tamaki Journal: J Am Acad Dermatol Date: 2000-06 Impact factor: 11.527
Authors: N Bangsgaard; K Engkilde; J P Thyssen; A Linneberg; N H Nielsen; T Menné; L Skov; J D Johansen Journal: Br J Dermatol Date: 2009-07-14 Impact factor: 9.302