Literature DB >> 3110532

1-Acyl-2-acetyl-sn-glycero-3-phosphocholine from stimulated human polymorphonuclear leukocytes.

K Satouchi, M Oda, K Saito.   

Abstract

1-Acyl-2-acetyl-sn-glycero-3-phosphocholine (1-acyl-2-acetyl GPC) was found in the fraction of platelet-activating factor obtained from stimulated human polymorphonuclear leukocytes (PMN). The amount of 1-acyl-2-acetyl GPC obtained from 1 X 10(7) PMN stimulated with ionophore A23187 at 37 C for 15 min ranged from 8 to 56 pmol (32 +/- 10 pmol, mean +/- standard error; n = 4). The main species was 16:0 palmitoyl (17 +/- 5 pmol), followed by 18:0 stearoyl (8 +/- 3 pmol) and 18:1 oleoyl (7 +/- 3 pmol). Although the physiological significance is unknown, 1-acyl-2-acetyl GPC was always detected when 1-alkyl-2-acetyl GPC was detected.

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Year:  1987        PMID： 3110532     DOI： 10.1007/bf02533994

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  21 in total

Review 1.  Platelet activating factor: a biologically active phosphoglyceride.

Authors:  D J Hanahan
Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

2.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

3.  Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+.

Authors:  J C Ludwig; L M McManus; P O Clark; D J Hanahan; R N Pinckard
Journal:  Arch Biochem Biophys       Date:  1984-07       Impact factor: 4.013

4.  Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes.

Authors:  S T Weintraub; J C Ludwig; G E Mott; L M McManus; C Lear; R N Pinckard
Journal:  Biochem Biophys Res Commun       Date:  1985-06-28       Impact factor: 3.575

5.  A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).

Authors:  M L Blank; T Lee; V Fitzgerald; F Snyder
Journal:  J Biol Chem       Date:  1981-01-10       Impact factor: 5.157

6.  Structure elucidation of platelet activating factor derived from human neutrophils.

Authors:  K L Clay; R C Murphy; J L Andres; J Lynch; P M Henson
Journal:  Biochem Biophys Res Commun       Date:  1984-06-29       Impact factor: 3.575

7.  Inactivation of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by a plasma acetylhydrolase: higher activities in hypertensive rats.

Authors:  M L Blank; M N Hall; E A Cress; F Snyder
Journal:  Biochem Biophys Res Commun       Date:  1983-06-15       Impact factor: 3.575

8.  Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor.

Authors:  K Satouchi; M Oda; K Yasunaga; K Saito
Journal:  Biochem Biophys Res Commun       Date:  1985-05-16       Impact factor: 3.575

9.  The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils.

Authors:  H W Mueller; J T O'Flaherty; R L Wykle
Journal:  J Biol Chem       Date:  1984-12-10       Impact factor: 5.157

10.  Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes.

Authors:  R N Pinckard; E M Jackson; C Hoppens; S T Weintraub; J C Ludwig; L M McManus; G E Mott
Journal:  Biochem Biophys Res Commun       Date:  1984-07-18       Impact factor: 3.575
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  7 in total

1.  Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein.

Authors:  D C Tsoukatos; T A Liapikos; A D Tselepis; M J Chapman; E Ninio
Journal:  Biochem J       Date:  2001-07-15       Impact factor: 3.857

Review 2.  Structural and (patho)physiological diversity of PAF.

Authors:  R N Pinckard; D S Woodard; H J Showell; M J Conklyn; M J Novak; L M McManus
Journal:  Clin Rev Allergy       Date:  1994

Review 3.  Metabolic processing of PAF.

Authors:  F Snyder
Journal:  Clin Rev Allergy       Date:  1994

4.  Studies on the role of platelet-activating factor in blood pressure regulation.

Authors:  K Sakaguchi; S Morimoto; F Masugi; S Saeki; T Ogihara; K Yamada; I Yamatsu
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

5.  Structure and thermotropic properties of 1-stearoyl-2-acetyl-phosphatidylcholine bilayer membranes.

Authors:  J Shah; R I Duclos; G G Shipley
Journal:  Biophys J       Date:  1994-05       Impact factor: 4.033

6.  Molecular heterogeneity of platelet-activating factor (PAF) in rat glandular stomach determined by gas chromatography/mass spectrometry. PAF molecular species changes upon water-immersion stress.

Authors:  J Sugatani; K Fujimura; M Miwa; K Satouchi; K Saito
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

7.  The metabolism of 1-acyl-PAF in rabbit platelets and its possible interaction with PAF.

Authors:  L Touqui; C S Silva; B B Vargaftig
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
  7 in total

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