Linlin Wang1, Longfei Li2, Chunyu Huang1, Lianghui Diao1, Ruochun Lian1, Yuye Li1, Shan Xiao1, Xiuyu Hu1, Meilan Mo1, Yong Zeng3. 1. Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, People's Republic of China. 2. Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, People's Republic of China; Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, People's Republic of China. 3. Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Shenzhen Zhongshan Urology Hospital, Shenzhen, Guangdong, People's Republic of China. Electronic address: zengyong1966@sina.com.
Abstract
OBJECTIVE: To evaluate whether maternal chronic hepatitis B virus (HBV) infection affects pregnancy outcomes in infertile patients undergoing their first in vitro fertilization (IVF) treatment. DESIGN: A retrospective case control study. SETTING: Fertility center. PATIENT(S): Female patients, comprising 8,550 infertile women including 180 HBsAg+HBeAg+, 714 HBsAg+HBeAg-, and 7,656 HBsAg seronegative controls undergoing their first IVF treatments. INTERVENTION(S): Clinical characteristics, pregnancy and neonatal outcomes were analyzed by Kruskal-Wallis test, analysis of variance, or chi-square test. Logistic regression was employed to verify the contribution of maternal HBV to clinical pregnancy, live birth, and miscarriage. MAIN OUTCOME MEASURE(S): Primary outcome: live-birth rate; secondary outcomes: implantation, clinical pregnancy, and miscarriage rates. RESULT(S): An increased duration of infertility and more secondary infertility and ovulatory disorders were observed in the HBV patients. The implantation rate was statistically significantly lower in the HBsAg+HBeAg- group compared with the controls. However, the clinical pregnancy rate, miscarriage rate, live-birth rate, neonatal outcomes, and pregnancy complications showed no statistically significant differences among the groups. The logistic regression analysis showed that HBV infection status did not affect the clinical pregnancy, miscarriage, or live-birth rates, unlike maternal age, endometrial thickness, and use of high-quality embryos. CONCLUSION(S): Hepatitis B virus infection is not an independent contributor to pregnancy outcomes, although it is associated with prolonged infertility duration, a high frequency of secondary infertility and ovulatory disorders, and a reduced implantation rate.
OBJECTIVE: To evaluate whether maternal chronic hepatitis B virus (HBV) infection affects pregnancy outcomes in infertilepatients undergoing their first in vitro fertilization (IVF) treatment. DESIGN: A retrospective case control study. SETTING: Fertility center. PATIENT(S): Female patients, comprising 8,550 infertilewomen including 180 HBsAg+HBeAg+, 714 HBsAg+HBeAg-, and 7,656 HBsAg seronegative controls undergoing their first IVF treatments. INTERVENTION(S): Clinical characteristics, pregnancy and neonatal outcomes were analyzed by Kruskal-Wallis test, analysis of variance, or chi-square test. Logistic regression was employed to verify the contribution of maternal HBV to clinical pregnancy, live birth, and miscarriage. MAIN OUTCOME MEASURE(S): Primary outcome: live-birth rate; secondary outcomes: implantation, clinical pregnancy, and miscarriage rates. RESULT(S): An increased duration of infertility and more secondary infertility and ovulatory disorders were observed in the HBVpatients. The implantation rate was statistically significantly lower in the HBsAg+HBeAg- group compared with the controls. However, the clinical pregnancy rate, miscarriage rate, live-birth rate, neonatal outcomes, and pregnancy complications showed no statistically significant differences among the groups. The logistic regression analysis showed that HBV infection status did not affect the clinical pregnancy, miscarriage, or live-birth rates, unlike maternal age, endometrial thickness, and use of high-quality embryos. CONCLUSION(S): Hepatitis B virus infection is not an independent contributor to pregnancy outcomes, although it is associated with prolonged infertility duration, a high frequency of secondary infertility and ovulatory disorders, and a reduced implantation rate.
Authors: Adão Francisco Lucas; Dibaba B Gemechu; Stefan S Du Plessis; Yapo G Aboua Journal: J Assist Reprod Genet Date: 2021-02-08 Impact factor: 3.412