Literature DB >> 31102440

Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome-like Clinical Presentation in Human Immunodeficiency Virus-infected Children in Malawi.

Nader Kim El-Mallawany1,2, William Kamiyango3, Jimmy Villiera3, Erin C Peckham-Gregory1,2, Michael E Scheurer1,2, Casey L McAtee1,2, Carl E Allen1,2, Carrie L Kovarik4, Dale Frank4, Anthony B Eason5, Carolina Caro-Vegas5, Elizabeth Y Chiao6,7, Gordon E Schutze1,8, Nmazuo W Ozuah1,2, Parth S Mehta1,2, Peter N Kazembe3, Dirk P Dittmer5.   

Abstract

We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both demonstrating extreme elevations of KSHV viral load and interleukin 6.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Kaposi sarcoma; Kaposi sarcoma herpesvirus; Kaposi sarcoma herpesvirus inflammatory cytokine syndrome; human herpesvirus 8; pediatric oncology

Year:  2019        PMID： 31102440      PMCID： PMC6853646          DOI： 10.1093/cid/ciz250

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  14 in total

1.  An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease.

Authors:  Thomas S Uldrick; Victoria Wang; Deirdre O'Mahony; Karen Aleman; Kathleen M Wyvill; Vickie Marshall; Seth M Steinberg; Stefania Pittaluga; Irina Maric; Denise Whitby; Giovanna Tosato; Richard F Little; Robert Yarchoan
Journal:  Clin Infect Dis       Date:  2010-08-01       Impact factor: 9.079

2.  HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

Authors:  Jan-Inge Henter; Annacarin Horne; Maurizio Aricó; R Maarten Egeler; Alexandra H Filipovich; Shinsaku Imashuku; Stephan Ladisch; Ken McClain; David Webb; Jacek Winiarski; Gritta Janka
Journal:  Pediatr Blood Cancer       Date:  2007-02       Impact factor: 3.167

3.  Life-threatening exacerbation of Kaposi's sarcoma after prednisone treatment for immune reconstitution inflammatory syndrome.

Authors:  Patricia F Volkow; Patricia Cornejo; Juan W Zinser; Christopher E Ormsby; Gustavo Reyes-Terán
Journal:  AIDS       Date:  2008-03-12       Impact factor: 4.177

Review 4.  How I treat hemophagocytic lymphohistiocytosis.

Authors:  Michael B Jordan; Carl E Allen; Sheila Weitzman; Alexandra H Filipovich; Kenneth L McClain
Journal:  Blood       Date:  2011-08-09       Impact factor: 22.113

5.  Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).

Authors:  Mark N Polizzotto; Thomas S Uldrick; Kathleen M Wyvill; Karen Aleman; Vickie Marshall; Victoria Wang; Denise Whitby; Stefania Pittaluga; Elaine S Jaffe; Corina Millo; Giovanna Tosato; Richard F Little; Seth M Steinberg; Irini Sereti; Robert Yarchoan
Journal:  Clin Infect Dis       Date:  2015-12-12       Impact factor: 9.079

6.  Clinical Manifestations of Kaposi Sarcoma Herpesvirus Lytic Activation: Multicentric Castleman Disease (KSHV-MCD) and the KSHV Inflammatory Cytokine Syndrome.

Authors:  Mark N Polizzotto; Thomas S Uldrick; Duosha Hu; Robert Yarchoan
Journal:  Front Microbiol       Date:  2012-03-02       Impact factor: 5.640

7.  Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study.

Authors:  Nader Kim El-Mallawany; William Kamiyango; Jeremy S Slone; Jimmy Villiera; Carrie L Kovarik; Carrie M Cox; Dirk P Dittmer; Saeed Ahmed; Gordon E Schutze; Michael E Scheurer; Peter N Kazembe; Parth S Mehta
Journal:  PLoS One       Date:  2016-04-15       Impact factor: 3.240

8.  Proposal of a Risk-Stratification Platform to Address Distinct Clinical Features of Pediatric Kaposi Sarcoma in Lilongwe, Malawi.

Authors:  Nader Kim El-Mallawany; William Kamiyango; Jimmy Villiera; Jeremy S Slone; Carrie L Kovarik; Liane R Campbell; Anurag K Agrawal; Dirk P Dittmer; Anthony B Eason; Saeed Ahmed; Gordon E Schutze; Michael E Scheurer; Peter N Kazembe; Parth S Mehta
Journal:  J Glob Oncol       Date:  2017-12-22

9.  Characteristics and survival for HIV-associated multicentric Castleman disease in Malawi.

Authors:  Satish Gopal; N George Liomba; Nathan D Montgomery; Agnes Moses; Bongani Kaimila; Richard Nyasosela; Maria Chikasema; Bal M Dhungel; Coxcilly Kampani; Marcia K Sanders; Robert Krysiak; Dirk P Dittmer; Yuri Fedoriw
Journal:  J Int AIDS Soc       Date:  2015-08-03       Impact factor: 5.396

Review 10.  Pediatric Kaposi sarcoma in context of the HIV epidemic in sub-Saharan Africa: current perspectives.

Authors:  Nader Kim El-Mallawany; Casey L McAtee; Liane R Campbell; Peter N Kazembe
Journal:  Pediatric Health Med Ther       Date:  2018-04-19
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  3 in total

1.  Whole-genome sequencing of Kaposi sarcoma-associated herpesvirus (KSHV/HHV8) reveals evidence for two African lineages.

Authors:  Razia Moorad; Angelica Juarez; Justin T Landis; Linda J Pluta; Megan Perkins; Avery Cheves; Dirk P Dittmer
Journal:  Virology       Date:  2022-02-02       Impact factor: 3.616

2.  Long-term outcomes for children and adolescents with Kaposi sarcoma.

Authors:  Allison Silverstein; William Kamiyango; Jimmy Villiera; Erin C Peckham-Gregory; Casey L McAtee; Michael E Scheurer; Carrie M Cox; Carrie L Kovarik; Liane R Campbell; Carl E Allen; Parth S Mehta; Peter N Kazembe; Nmazuo W Ozuah; Nader Kim El-Mallawany
Journal:  HIV Med       Date:  2021-10-11       Impact factor: 3.094

3.  Valganciclovir as Add-On Therapy Modifies the Frequency of NK and NKT Cell Subpopulations in Disseminated Kaposi Sarcoma Patients.

Authors:  Julio Flores-Gonzalez; Lucero A Ramon-Luing; Ranferi Ocaña-Guzman; Ivette Buendia-Roldan; Beda Islas-Muñoz; Patricia Volkow-Fernández; Leslie Chavez-Galan
Journal:  Cancers (Basel)       Date:  2022-01-14       Impact factor: 6.639
  3 in total

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