Ali Seven1, Esin Yalinbas2, Suna Kabil Kucur3, Emel Kocak4, Ozben Isiklar5, Beril Yuksel3, Hakan Timur6, Mehmet Erbakirci3, Nadi Keskin3. 1. Department of Obstetrics and Gynecology Kutahya, Dumlupinar University School of Medicine, Kütahya, Turkey. draliseven@hotmail.com. 2. Department of Pediatrics Kutahya, Dumlupinar University School of Medicine, Kütahya, Turkey. 3. Department of Obstetrics and Gynecology Kutahya, Dumlupinar University School of Medicine, Kütahya, Turkey. 4. Department of Biochemistry Kutahya, Dumlupinar University School of Medicine, Kütahya, Turkey. 5. Department of Biochemistry Kutahya, Dumlupinar University Kutahya Evliya Celebi Training and Research Hospital, Kütahya, Turkey. 6. Department of Obstetrics and Gynecology Ankara, Zekai Tahir Burak Women's Health Training and Research Hospital, Kütahya, Turkey.
Abstract
AIM: To evaluate maternal and cord blood irisin levels in pregnant women with gestational diabetes mellitus (GDM) and in obese pregnant women without GDM. METHODS: The study included 109 patients, with 34 patients in the GDM group, 40 in the obese non-GDM group, and 35 in the control group. Maternal serum irisin levels at the time of delivery were measured by an enzyme-linked immunosorbent assay kit. The correlation of serum irisin levels with metabolic parameters and anthropometric measurements was analyzed. RESULTS: There were significant differences between the study groups in terms of cord arterial, cord venous, and maternal serum irisin levels (P < 0.001, P < 0.01, P < 0.001, respectively). Cord arterial, cord venous, and maternal serum irisin levels were higher in the obese group compared to the control (P < 0.01, P < 0.01, P < 0.01, respectively) and the GDM group (P < 0.001, P < 0.001, P < 0.001, respectively). CONCLUSION: Elevation in irisin levels of women who have pregnancies complicated with obesity may be explained as part of the compensation mechanism against disturbed metabolic functions. Pregnant individuals with GDM have lower serum irisin levels in comparison to healthy pregnant women. In this regard, it is possible that the measurement of serum irisin levels may be utilized in the future for prediction, prevention, and treatment of GDM.
AIM: To evaluate maternal and cord blood irisin levels in pregnant women with gestational diabetes mellitus (GDM) and in obese pregnant women without GDM. METHODS: The study included 109 patients, with 34 patients in the GDM group, 40 in the obese non-GDM group, and 35 in the control group. Maternal serum irisin levels at the time of delivery were measured by an enzyme-linked immunosorbent assay kit. The correlation of serum irisin levels with metabolic parameters and anthropometric measurements was analyzed. RESULTS: There were significant differences between the study groups in terms of cord arterial, cord venous, and maternal serum irisin levels (P < 0.001, P < 0.01, P < 0.001, respectively). Cord arterial, cord venous, and maternal serum irisin levels were higher in the obese group compared to the control (P < 0.01, P < 0.01, P < 0.01, respectively) and the GDM group (P < 0.001, P < 0.001, P < 0.001, respectively). CONCLUSION: Elevation in irisin levels of women who have pregnancies complicated with obesity may be explained as part of the compensation mechanism against disturbed metabolic functions. Pregnant individuals with GDM have lower serum irisin levels in comparison to healthy pregnant women. In this regard, it is possible that the measurement of serum irisin levels may be utilized in the future for prediction, prevention, and treatment of GDM.
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