Ronaldo Lira-Junior1,2, Mayla K S Teixeira3, Eduardo J V Lourenço3, Daniel M Telles3, Carlos Marcelo Figueredo2,4,5, Elisabeth A Boström6. 1. Department of Dental Medicine, Division of Oral Diseases, Karolinska Institute, Stockholm, Sweden. 2. Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil. 3. Department of Prosthodontics, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil. 4. School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia. 5. Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia. 6. Department of Dental Medicine, Division of Oral Diseases, Karolinska Institute, Stockholm, Sweden. elisabeth.bostrom@ki.se.
Abstract
OBJECTIVE: Colony-stimulating factor (CSF)-1 and interleukin (IL)-34 are growth factors that regulate myeloid cell functions and support osteoclastogenesis. CSF-1 and IL-34 levels in peri-implant diseases are yet unknown. This study evaluated CSF-1, IL-34, and IL-1β levels in saliva and peri-implant crevicular fluid (PICF) from patients having mucositis or peri-implantitis, as well as their correlation to clinical parameters of disease. MATERIAL AND METHODS: Forty-three patients were included (mean age 61.1 ± 8.4; 62.8% female), 20 having mucositis and 23 having peri-implantitis. Patients were clinically examined and unstimulated whole saliva and PICF were collected. Levels of CSF-1, IL-34, and IL-1β were determined by enzyme-linked immunosorbent assays. RESULTS: CSF-1 levels were higher in PICF from peri-implantitis compared with mucositis patients (p = 0.028), whereas IL-34 levels showed no significant difference between the groups (p = 0.060). No significant difference was found in PICF IL-1β levels between the groups. Salivary levels of CSF-1 and IL-34 did not differ significantly between mucositis and peri-implantitis. No significant difference was observed in the salivary levels of IL-1β between groups (p = 0.061). CSF-1 and IL-1β correlated significantly in both saliva and PICF. CSF-1 levels in saliva correlated with its levels in PICF. PICF CSF-1 levels showed potential to discriminate between peri-implantitis and mucositis (AUC = 0.695, 95% CI 0.53-0.85; p = 0.029). CONCLUSION: Increased levels of CSF-1 in peri-implant crevicular fluid, but not in saliva, were found in peri-implantitis patients, which might aid to discriminate the early and late stages of peri-implant diseases. CLINICAL RELEVANCE: This result suggests an increased osteoclastogenic potential in peri-implantitis patients.
OBJECTIVE:Colony-stimulating factor (CSF)-1 and interleukin (IL)-34 are growth factors that regulate myeloid cell functions and support osteoclastogenesis. CSF-1 and IL-34 levels in peri-implant diseases are yet unknown. This study evaluated CSF-1, IL-34, and IL-1β levels in saliva and peri-implant crevicular fluid (PICF) from patients having mucositis or peri-implantitis, as well as their correlation to clinical parameters of disease. MATERIAL AND METHODS: Forty-three patients were included (mean age 61.1 ± 8.4; 62.8% female), 20 having mucositis and 23 having peri-implantitis. Patients were clinically examined and unstimulated whole saliva and PICF were collected. Levels of CSF-1, IL-34, and IL-1β were determined by enzyme-linked immunosorbent assays. RESULTS:CSF-1 levels were higher in PICF from peri-implantitis compared with mucositispatients (p = 0.028), whereas IL-34 levels showed no significant difference between the groups (p = 0.060). No significant difference was found in PICF IL-1β levels between the groups. Salivary levels of CSF-1 and IL-34 did not differ significantly between mucositis and peri-implantitis. No significant difference was observed in the salivary levels of IL-1β between groups (p = 0.061). CSF-1 and IL-1β correlated significantly in both saliva and PICF. CSF-1 levels in saliva correlated with its levels in PICF. PICF CSF-1 levels showed potential to discriminate between peri-implantitis and mucositis (AUC = 0.695, 95% CI 0.53-0.85; p = 0.029). CONCLUSION: Increased levels of CSF-1 in peri-implant crevicular fluid, but not in saliva, were found in peri-implantitispatients, which might aid to discriminate the early and late stages of peri-implant diseases. CLINICAL RELEVANCE: This result suggests an increased osteoclastogenic potential in peri-implantitispatients.
Authors: Haishan Lin; Ernestine Lee; Kevin Hestir; Cindy Leo; Minmei Huang; Elizabeth Bosch; Robert Halenbeck; Ge Wu; Aileen Zhou; Dirk Behrens; Diane Hollenbaugh; Thomas Linnemann; Minmin Qin; Justin Wong; Keting Chu; Stephen K Doberstein; Lewis T Williams Journal: Science Date: 2008-05-09 Impact factor: 47.728
Authors: Hajer A Aldulaijan; Abeer S Al-Zawawi; Marwa Y Shaheen; Dena Ali; Darshan Devang Divakar; Amani M Basudan Journal: Int J Implant Dent Date: 2022-07-14