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Literature DB >> 31101675

Mitochondria and pathogen immunity: from killer to firestarter.

Abstract

Serving as an innate defence mechanism, invading pathogens elicit a broad inflammatory response in cells. In this issue, Brokatzky et al (2019) report that pathogens can cause activation of BAX/BAK which permeabilises a limited number of mitochondria. Induction of DNA damage, or release of mtDNA, triggers STING-dependent pro-inflammatory cytokine expression and secretion, revealing an unexpected role for the mitochondrial apoptotic machinery in immune defence.

Entities: Gene

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Year: 2019 PMID： 31101675 PMCID： PMC6545555 DOI： 10.15252/embj.2019102325

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

12 in total

1. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.

Authors: Kristopher A Sarosiek; Cameron Fraser; Nathiya Muthalagu; Patrick D Bhola; Weiting Chang; Samuel K McBrayer; Adam Cantlon; Sudeshna Fisch; Gail Golomb-Mello; Jeremy A Ryan; Jing Deng; Brian Jian; Chris Corbett; Marti Goldenberg; Joseph R Madsen; Ronglih Liao; Dominic Walsh; John Sedivy; Daniel J Murphy; Daniel Ruben Carrasco; Shenandoah Robinson; Javid Moslehi; Anthony Letai
Journal: Cancer Cell Date: 2016-12-22 Impact factor: 31.743

Review 2. Caspase functions in cell death and disease.

Authors: David R McIlwain; Thorsten Berger; Tak W Mak
Journal: Cold Spring Harb Perspect Biol Date: 2013-04-01 Impact factor: 10.005

3. A non-death function of the mitochondrial apoptosis apparatus in immunity.

Authors: Dominik Brokatzky; Benedikt Dörflinger; Aladin Haimovici; Arnim Weber; Susanne Kirschnek; Juliane Vier; Arlena Metz; Julia Henschel; Tobias Steinfeldt; Ian E Gentle; Georg Häcker
Journal: EMBO J Date: 2019-04-12 Impact factor: 11.598

4. BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

Authors: Kate McArthur; Lachlan W Whitehead; John M Heddleston; Lucy Li; Benjamin S Padman; Viola Oorschot; Niall D Geoghegan; Stephane Chappaz; Sophia Davidson; Hui San Chin; Rachael M Lane; Marija Dramicanin; Tahnee L Saunders; Canny Sugiana; Romina Lessene; Laura D Osellame; Teng-Leong Chew; Grant Dewson; Michael Lazarou; Georg Ramm; Guillaume Lessene; Michael T Ryan; Kelly L Rogers; Mark F van Delft; Benjamin T Kile
Journal: Science Date: 2018-02-23 Impact factor: 47.728

5. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.

Authors: Michael J White; Kate McArthur; Donald Metcalf; Rachael M Lane; John C Cambier; Marco J Herold; Mark F van Delft; Sammy Bedoui; Guillaume Lessene; Matthew E Ritchie; David C S Huang; Benjamin T Kile
Journal: Cell Date: 2014-12-18 Impact factor: 41.582

6. Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Authors: Anthony Rongvaux; Ruaidhrí Jackson; Christian C D Harman; Tuo Li; A Phillip West; Marcel R de Zoete; Youtong Wu; Brian Yordy; Saquib A Lakhani; Chia-Yi Kuan; Tadatsugu Taniguchi; Gerald S Shadel; Zhijian J Chen; Akiko Iwasaki; Richard A Flavell
Journal: Cell Date: 2014-12-18 Impact factor: 41.582

7. Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Authors: Gabriel Ichim; Jonathan Lopez; Shafiq U Ahmed; Nathiya Muthalagu; Evangelos Giampazolias; M Eugenia Delgado; Martina Haller; Joel S Riley; Susan M Mason; Dimitris Athineos; Melissa J Parsons; Bert van de Kooij; Lisa Bouchier-Hayes; Anthony J Chalmers; Rogier W Rooswinkel; Andrew Oberst; Karen Blyth; Markus Rehm; Daniel J Murphy; Stephen W G Tait
Journal: Mol Cell Date: 2015-02-19 Impact factor: 17.970

8. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Authors: Evangelos Giampazolias; Barbara Zunino; Sandeep Dhayade; Florian Bock; Catherine Cloix; Kai Cao; Alba Roca; Jonathan Lopez; Gabriel Ichim; Emma Proïcs; Camila Rubio-Patiño; Loic Fort; Nader Yatim; Emma Woodham; Susana Orozco; Lucia Taraborrelli; Nieves Peltzer; Daniele Lecis; Laura Machesky; Henning Walczak; Matthew L Albert; Simon Milling; Andrew Oberst; Jean-Ehrland Ricci; Kevin M Ryan; Karen Blyth; Stephen W G Tait
Journal: Nat Cell Biol Date: 2017-08-28 Impact factor: 28.824

9. Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.

Authors: Gillian Dunphy; Sinéad M Flannery; Jessica F Almine; Dympna J Connolly; Christina Paulus; Kasper L Jønsson; Martin R Jakobsen; Michael M Nevels; Andrew G Bowie; Leonie Unterholzner
Journal: Mol Cell Date: 2018-09-06 Impact factor: 17.970

10. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.

Authors: Joel S Riley; Giovanni Quarato; Catherine Cloix; Jonathan Lopez; Jim O'Prey; Matthew Pearson; James Chapman; Hiromi Sesaki; Leo M Carlin; João F Passos; Ann P Wheeler; Andrew Oberst; Kevin M Ryan; Stephen Wg Tait
Journal: EMBO J Date: 2018-07-26 Impact factor: 11.598

5 in total

Review 1. Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection.

Authors: Kristin L Patrick; Robert O Watson
Journal: Infect Immun Date: 2021-03-17 Impact factor: 3.441

Review 2. Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer.

Authors: Hang Yang; Bin Wei; Bing Hu
Journal: Inflamm Res Date: 2021-09-21 Impact factor: 4.575