Emanuele Zaffuto1, Marco Bandini2, Marco Moschini3, Sami-Ramzi Leyh-Bannurah4, Stéphanie Gazdovich5, Paolo Dell'Oglio3, Andrea Gallina3, Shahrokh F Shariat6, Alberto Briganti3, Francesco Montorsi3, Fred Saad5, Pierre I Karakiewicz5. 1. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada; Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. 2. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada; Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. Electronic address: marco.bandini.zoli@gmail.com. 3. Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. 4. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada; Martini Clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany. 5. Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Canada. 6. Department of Urology, Medical University of Vienna, Vienna, Austria.
Abstract
BACKGROUND: A recent study of a highly select cohort suggested a survival benefit when local treatment is delivered in patients with metastatic bladder cancer (BCa). OBJECTIVE: We examined in-hospital mortality (IHM) rates according to the presence, absence, and location of metastatic disease in a similar highly select cohort of BCa patients treated with radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS: We used data for 25 004 BCa patients included in the National Inpatients Sample (NIS) database between 1998 and 2013. INTERVENTION: Radical cystectomy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We tested postoperative IHM rates according to the presence of metastases and the location of metastatic disease (exclusive nodal vs distant metastases). Multivariable logistic regression analyses were adjusted for age, gender, race, comorbidities, length of hospitalization, hospital location, teaching status, hospital surgical volume, and bed size. RESULTS AND LIMITATIONS: Among 25 004 BCa patients treated with RC, 3830 (14.4%) had nonregional lymph node metastases (NRNM), 693 (2.8%) had distant metastases (DM), and 19 965 (79.8%) had nonmetastatic disease. Virtually all patients with metastatic BCa had a single metastatic focus (n=4020; 93.7%). In multivariable logistic regression analyses, DM (odds ratio [OR] 2.31, 95% confidence interval [CI] 1.57-3.28; p<0.001) but not NRNM (OR 0.88, 95% CI 0.66-1.15; p=0.4) was associated with higher risk of IHM. The absence of information on preoperative chemotherapy and the retrospective study design may limit our findings. CONCLUSIONS: The risk of IHM for highly select individuals with NRNM treated with RC is similar to that for patients with nonmetastatic BCa. Conversely, patients with DM are at higher risk of IHM compared to patients with NRNM. PATIENT SUMMARY: According to existing data, radical cystectomy in the metastatic bladder cancer setting should be limited to patients with nonregional lymph node metastases, if at all indicated.
BACKGROUND: A recent study of a highly select cohort suggested a survival benefit when local treatment is delivered in patients with metastatic bladder cancer (BCa). OBJECTIVE: We examined in-hospital mortality (IHM) rates according to the presence, absence, and location of metastatic disease in a similar highly select cohort of BCa patients treated with radical cystectomy (RC). DESIGN, SETTING, AND PARTICIPANTS: We used data for 25 004 BCa patients included in the National Inpatients Sample (NIS) database between 1998 and 2013. INTERVENTION: Radical cystectomy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We tested postoperative IHM rates according to the presence of metastases and the location of metastatic disease (exclusive nodal vs distant metastases). Multivariable logistic regression analyses were adjusted for age, gender, race, comorbidities, length of hospitalization, hospital location, teaching status, hospital surgical volume, and bed size. RESULTS AND LIMITATIONS: Among 25 004 BCa patients treated with RC, 3830 (14.4%) had nonregional lymph node metastases (NRNM), 693 (2.8%) had distant metastases (DM), and 19 965 (79.8%) had nonmetastatic disease. Virtually all patients with metastatic BCa had a single metastatic focus (n=4020; 93.7%). In multivariable logistic regression analyses, DM (odds ratio [OR] 2.31, 95% confidence interval [CI] 1.57-3.28; p<0.001) but not NRNM (OR 0.88, 95% CI 0.66-1.15; p=0.4) was associated with higher risk of IHM. The absence of information on preoperative chemotherapy and the retrospective study design may limit our findings. CONCLUSIONS: The risk of IHM for highly select individuals with NRNM treated with RC is similar to that for patients with nonmetastatic BCa. Conversely, patients with DM are at higher risk of IHM compared to patients with NRNM. PATIENT SUMMARY: According to existing data, radical cystectomy in the metastatic bladder cancer setting should be limited to patients with nonregional lymph node metastases, if at all indicated.
Authors: Giuseppe Rosiello; Angela Pecoraro; Marina Deuker; Lara Franziska Stolzenbach; Thomas Martin; Zhe Tian; Alessandro Larcher; Umberto Capitanio; Francesco Montorsi; Shahrokh F Shariat; Anil Kapoor; Fred Saad; Alberto Briganti; Pierre I Karakiewicz Journal: Int J Clin Oncol Date: 2021-01-30 Impact factor: 3.402
Authors: Marco Moschini; Evanguelos Xylinas; Stefania Zamboni; Agostino Mattei; Günter Niegisch; Evan Y Yu; Aristotelis Bamias; Neeraj Agarwal; Srikala S Sridhar; Cora N Sternberg; Ulka N Vaishampayan; Jonathan E Rosenberg; Joaquim Bellmunt; Matthew D Galsky; Francesco Montorsi; Andrea Necchi Journal: Eur Urol Oncol Date: 2019-07-13
Authors: Giuseppe Rosiello; Carlotta Palumbo; Marina Deuker; Lara Franziska Stolzenbach; Thomas Martin; Zhe Tian; Andrea Gallina; Francesco Montorsi; Peter Black; Wassim Kassouf; Shahrokh F Shariat; Fred Saad; Alberto Briganti; Pierre I Karakiewicz Journal: Cent European J Urol Date: 2020-10-31